Acteoside protects against 6-OHDA-induced dopaminergic neuron damage via Nrf2-ARE signaling pathway.

Abstract

Acteoside has been reported to have antioxidant and neuroprotective effect, which is a promising therapeutic way in prevention and treatment of Parkinson's disease. The present study was aimed to understand the neuroprotective effect of acteoside and to elucidate its underlying mechanism. 6-hydroxydopamine (6-OHDA)-induced neural damage in zebrafish model was used to study the protective effect of acteoside on Parkinson's disease (PD). Locomotion behavioral test showed that acteoside could prevent 6-OHDA-stimulated movement disorders. Anti-tyrosine hydroxylase (TH) whole-mount immunostaining analysis showed that acteoside could prevent 6-OHDA-induced dopaminergic neuron death. In addition, pretreatment with acteoside could upregulate antioxidative enzymes by activating the Nrf2/ARE signaling pathway in zebrafish. Meanwhile, acteoside was found to be distributed in the brain after intraperitoneal injection into the adult zebrafish, indicating that this compound could penetrate the blood-brain-barrier (BBB). This study demonstrated that acteoside could penetrate BBB and have potential therapeutic value for PD by activating the Nrf2/ARE signaling pathway and attenuating the oxidative stress.

• Authors: Maiquan Li, Fei Zhou, Tao Xu, Huaxin Song, Baiyi Lu
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 119 Pg. 6-13 (Sep 2018) ISSN: 1873-6351 [Electronic] England
• PMID: 29906474 (Publication Type: Journal Article)
• Copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.

Chemical References

• Antioxidants
• Glucosides
• NF-E2-Related Factor 2
• Phenols
• Zebrafish Proteins
• nfe2l2a protein, zebrafish
• acteoside
• Malondialdehyde
• Oxidopamine
• Carboxylic Ester Hydrolases
• arylesterase

Topics

• Animals
• Antioxidants (metabolism)
• Carboxylic Ester Hydrolases (genetics, metabolism)
• Dopaminergic Neurons (drug effects)
• Gene Expression Regulation, Enzymologic (drug effects)
• Glucosides (pharmacology)
• Larva
• Malondialdehyde (metabolism)
• Metabolic Networks and Pathways (drug effects)
• Motor Activity (drug effects)
• NF-E2-Related Factor 2 (genetics, metabolism)
• Oxidopamine (toxicity)
• Phenols (pharmacology)
• Zebrafish
• Zebrafish Proteins (genetics, metabolism)