Investigation of the Anti-Prostate Cancer Properties of Marine-Derived Compounds.

Abstract

This review focuses on marine compounds with anti-prostate cancer properties. Marine species are unique and have great potential for the discovery of anticancer drugs. Marine sources are taxonomically diverse and include bacteria, cyanobacteria, fungi, algae, and mangroves. Marine-derived compounds, including nucleotides, amides, quinones, polyethers, and peptides are biologically active compounds isolated from marine organisms such as sponges, ascidians, gorgonians, soft corals, and bryozoans, including those mentioned above. Several compound classes such as macrolides and alkaloids include drugs with anti-cancer mechanisms, such as antioxidants, anti-angiogenics, antiproliferatives, and apoptosis-inducing drugs. Despite the diversity of marine species, most marine-derived bioactive compounds have not yet been evaluated. Our objective is to explore marine compounds to identify new treatment strategies for prostate cancer. This review discusses chemically and pharmacologically diverse marine natural compounds and their sources in the context of prostate cancer drug treatment.

• Authors: Meiqi Fan, Amit Kumar Nath, Yujiao Tang, Young-Jin Choi, Trishna Debnath, Eun-Ju Choi, Eun-Kyung Kim
• Journal: Marine drugs (Mar Drugs) Vol. 16 Issue 5 (May 12 2018) ISSN: 1660-3397 [Electronic] Switzerland
• PMID: 29757237 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Biological Products

Topics

• Animals
• Antineoplastic Agents (chemistry, isolation & purification, pharmacology, therapeutic use)
• Aquatic Organisms (chemistry)
• Biological Products (chemistry, isolation & purification, pharmacology, therapeutic use)
• Drug Screening Assays, Antitumor (methods)
• Humans
• Male
• Molecular Targeted Therapy (methods)
• Prostatic Neoplasms (drug therapy, pathology)