Abstract | AIMS/HYPOTHESIS:
Incretin effect-the potentiation of glucose-stimulated insulin release induced by the oral vs the i.v. route-is impaired in dysglycaemic states. Despite evidence from human islet studies that NEFA interfere with incretin function, little information is available about the effect in humans. We tested the impact of acute bidirectional NEFA manipulation on the incretin effect in humans. METHODS: Thirteen individuals with type 2 diabetes and ten non-diabetic volunteers had a 3 h OGTT, and, a week later, an i.v. isoglycaemic glucose infusion (ISO; OGTT matched). Both pairs of studies were repeated during an exogenous lipid infusion in the non-diabetic volunteers, and following acipimox administration (to inhibit lipolysis) in people with diabetes. Mathematical modelling of insulin secretion dynamics assessed total insulin secretion (TIS), beta cell glucose sensitivity (β-GS), glucose-induced potentiation (PGLU) and incretin-induced potentiation (PINCR); the oral glucose sensitivity index was used to estimate insulin sensitivity. RESULTS: CONCLUSIONS/INTERPRETATION:
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Authors | Brenno Astiarraga, Valéria B Chueire, Aglécio L Souza, Ricardo Pereira-Moreira, Sarah Monte Alegre, Andrea Natali, Andrea Tura, Andrea Mari, Ele Ferrannini, Elza Muscelli |
Journal | Diabetologia
(Diabetologia)
Vol. 61
Issue 8
Pg. 1829-1837
(08 2018)
ISSN: 1432-0428 [Electronic] Germany |
PMID | 29732475
(Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Fatty Acids, Nonesterified
- Incretins
- Insulin
- Lipids
- Pyrazines
- Gastric Inhibitory Polypeptide
- Glucagon-Like Peptide 1
- Glucagon
- acipimox
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Topics |
- Adolescent
- Adult
- Blood Glucose
(analysis)
- Diabetes Mellitus, Type 2
(metabolism, pathology)
- Fatty Acids, Nonesterified
(metabolism)
- Gastric Inhibitory Polypeptide
(blood)
- Glucagon
(blood)
- Glucagon-Like Peptide 1
(blood)
- Glucose Tolerance Test
- Humans
- Incretins
(metabolism)
- Insulin
(metabolism)
- Insulin-Secreting Cells
(metabolism)
- Lipids
(chemistry)
- Middle Aged
- Pyrazines
(pharmacology)
- Time Factors
- Young Adult
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