Abstract | AIMS/INTRODUCTION: MATERIALS AND METHODS: Hypertensive patients without a history of diabetes and hypolipidemic agents were enrolled continuously at the Hypertension Clinic, Zhongshan Hospital, Fudan University (Shanghai, China) from 2014 to 2016. General clinical data, including body mass index, blood pressure, fasting glucose and 2-h post-load glucose levels, and lipid profiles, were collected. The LDL-C/HDL-C ratio, TG/HDL-C ratio and TC/HDL-C ratio were separately calculated. Statistical analyses were carried out by using SPSS software (version 13.0). RESULTS: In total, 935 hypertensive patients were included, of which 114 patients (12.2%) were diagnosed with diabetes. After multivariate adjustments, the LDL-C/HDL-C ratio and TG levels had the most significant and independent associations with diabetes. In the multivariate logistic regression, the LDL-C/HDL-C ratio and TG were independently associated with diabetes. After the interaction variable was included, the LDL-C/HDL-C ratio remained independently associated with diabetes, but TG was replaced by TG* LDL-C/HDL-C. CONCLUSIONS: In conclusion, elevated LDL-C/HDL-C ratios and TG levels were associated with diabetes in patients with hypertension, with an interactive effect of the LDL-C/HDL-C ratio and TG on diabetes in the hypertensive population.
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Authors | Mengyang Hong, Yan Ling, Zhiqiang Lu, Ying Liu, Ping Gu, Jiaqing Shao, Xin Gao, Xiaomu Li |
Journal | Journal of diabetes investigation
(J Diabetes Investig)
Vol. 10
Issue 1
Pg. 131-138
(Jan 2019)
ISSN: 2040-1124 [Electronic] Japan |
PMID | 29694714
(Publication Type: Journal Article)
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Copyright | © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd. |
Chemical References |
- Biomarkers
- Cholesterol, HDL
- Cholesterol, LDL
- Triglycerides
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Topics |
- Biomarkers
(blood)
- Cholesterol, HDL
(blood)
- Cholesterol, LDL
(blood)
- Cross-Sectional Studies
- Diabetes Complications
(blood)
- Diabetes Mellitus
(blood)
- Female
- Humans
- Hypertension
(blood, complications)
- Male
- Middle Aged
- Risk Factors
- Triglycerides
(blood)
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