Expression of platelet-derived growth factor B is upregulated in patients with thoracic aortic dissection.

Abstract

OBJECTIVE:

Thoracic aortic dissection (TAD) is a serious condition requiring urgent treatment to avoid catastrophic consequences. The inflammatory response is involved in the occurrence and development of TAD, possibly potentiated by platelet-derived growth factors (PDGFs). This study aimed to determine whether expression of PDGF-B (a subunit of PDGF-BB) was increased in TAD patients and to explore the factors responsible for its upregulation and subsequent effects on TAD.

METHODS:

Full-thickness ascending aorta wall specimens from TAD patients (n = 15) and control patients (n = 10) were examined for expression of PDGF-B and its receptor (PDGFRB) and in terms of morphology, inflammation, and fibrosis. Blood samples from TAD and control patients were collected to detect plasma levels of PDGF-BB and soluble elastins.

RESULTS:

Expression levels of PDGF-B, PDGFRB, and collagen I were significantly enhanced in ascending aorta wall specimens from TAD patients compared with controls. Furthermore, soluble elastic fragments and PDGF-BB were significantly increased in plasma from TAD patients compared with controls, and numerous irregular elastic fibers and macrophages were seen in the ascending aorta wall in TAD patients.

CONCLUSIONS:

An increase in elastic fragments in the aorta wall might be responsible for inducing the activation and migration of macrophages to injured sites, leading to elevated expression of PDGF-B, which in turn induces deposition of collagen, disrupts extracellular matrix homeostasis, and increases the stiffness of the aorta wall, resulting in compromised aorta compliance.

• Authors: Weixin Meng, Shangdian Liu, Dandan Li, Zonghong Liu, Hui Yang, Bo Sun, Hongyu Liu
• Journal: Journal of vascular surgery (J Vasc Surg) Vol. 68 Issue 6S Pg. 3S-13S (12 2018) ISSN: 1097-6809 [Electronic] United States
• PMID: 29685513 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2018 Society for Vascular Surgery. Published by Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Collagen Type I
• Proto-Oncogene Proteins c-sis
• Receptor, Platelet-Derived Growth Factor beta

Topics

• Adult
• Aortic Dissection (blood, pathology, physiopathology, surgery)
• Aorta, Thoracic (chemistry, pathology, physiopathology, surgery)
• Aortic Aneurysm, Thoracic (blood, pathology, physiopathology, surgery)
• Biomarkers (blood)
• Case-Control Studies
• Collagen Type I (analysis)
• Elastic Tissue (chemistry, pathology)
• Female
• Humans
• Male
• Middle Aged
• Proto-Oncogene Proteins c-sis (blood, genetics)
• Receptor, Platelet-Derived Growth Factor beta (analysis, genetics)
• Up-Regulation
• Vascular Remodeling
• Vascular Stiffness