Abstract |
Patients with depression and alcohol use disorder frequently present with elevated markers of inflammation. Adipose tissue may function as a source for inflammation, yet the interplay between adiposity, alcohol use and depression has remained unknown. We examined 242 patients, referred to treatment for depressive symptoms, and followed for a period of 6 months. The assessments included screening for alcohol use and measurements of body mass index, serum adiponectin, leptin, resistin, progranulin, hs-CRP, IL-6 and MCP-1 at baseline and after 6 months of treatment. During follow-up, mean MADRS and AUDIT scores decreased significantly, whereas BMI increased. The changes in the levels of cytokines and adipokines were influenced by alcohol consumption and adiposity in a gender-dependent manner. The presence of AUD seemed to particularly influence the levels of cytokines. The levels of IL-6, hs-CRP, progranulin, and leptin differed between AUD and non-AUD groups at baseline, but no longer at 6 months. Baseline levels of leptin and resistin were higher in women and changes occurring in leptin, progranulin, and adiponectin were more notable in women. The data indicates significant gender-dependent interactions between depression, alcohol and mediators of inflammation, which should be considered in studies on the pathogenesis of depression and its comorbidities.
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Authors | Mari Archer, Onni Niemelä, Mari Hämäläinen, Eeva Moilanen, Esa Leinonen, Olli Kampman |
Journal | Psychiatry research
(Psychiatry Res)
Vol. 264
Pg. 31-38
(06 2018)
ISSN: 1872-7123 [Electronic] Ireland |
PMID | 29626829
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2018 Elsevier B.V. All rights reserved. |
Chemical References |
- ADIPOQ protein, human
- Adipokines
- Adiponectin
- Biomarkers
- Cytokines
- Leptin
- RETN protein, human
- Resistin
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Topics |
- Adipokines
(blood)
- Adiponectin
(blood)
- Adiposity
(physiology)
- Adult
- Alcohol Drinking
(blood, psychology)
- Alcoholism
(blood, diagnosis, psychology)
- Biomarkers
(blood)
- Body Mass Index
- Cytokines
(blood)
- Depression
(blood, diagnosis, psychology)
- Female
- Follow-Up Studies
- Humans
- Inflammation
(blood, diagnosis, psychology)
- Leptin
(blood)
- Longitudinal Studies
- Male
- Middle Aged
- Obesity
(blood, diagnosis, psychology)
- Resistin
(blood)
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