Abstract | PURPOSE: Metastatic breast cancer is resistant to many conventional treatments and novel therapeutic targets are needed. We previously isolated subsets of 4T1 murine breast cancer cells which metastasized to liver (4TLM), brain (4TBM), and heart (4THM). Among these cells, 4TLM is the most aggressive one, demonstrating mesenchymal phenotype. Here we compared secreted proteins from 4TLM, 4TBM, and 4THM cells and compared with that of hardly metastatic 67NR cells to detect differentially secreted factors involved in organ-specific metastasis. METHOD AND RESULTS: CONCLUSIONS:
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Authors | Nuray Erin, Nur Ogan, Azmi Yerlikaya |
Journal | Breast cancer research and treatment
(Breast Cancer Res Treat)
Vol. 170
Issue 2
Pg. 235-250
(Jul 2018)
ISSN: 1573-7217 [Electronic] Netherlands |
PMID | 29557524
(Publication Type: Journal Article)
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Chemical References |
- Cytokines
- Proteome
- TGFB1 protein, human
- Transforming Growth Factor beta1
- Thymic Stromal Lymphopoietin
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Topics |
- Breast Neoplasms
(metabolism, pathology)
- Cell Line, Tumor
- Chromatography, Liquid
- Computational Biology
(methods)
- Cytokines
- Female
- Humans
- Neoplasm Metastasis
- Neoplasm Staging
- Proteome
- Proteomics
(methods)
- Signal Transduction
- Tandem Mass Spectrometry
- Transforming Growth Factor beta1
(metabolism)
- Thymic Stromal Lymphopoietin
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