Bone Morphogenetic Protein 1

A bone morphogenetic protein family member that includes an active tolloid-like metalloproteinase domain. The metalloproteinase activity of bone morphogenetic protein 1 is specific for the removal of the C-propeptide of PROCOLLAGEN and may act as a regulator of EXTRACELLULAR MATRIX deposition. Alternative splicing of MRNA for bone morphogenetic protein 1 results in the production of several PROTEIN ISOFORMS.

Also Known As:

Networked: 30 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Vukicevic, Slobodan: 3 articles (10/2022 - 04/2011)
2.	Bordukalo-Niksic, Tatjana: 2 articles (10/2022 - 12/2017)
3.	Dumic-Cule, Ivo: 2 articles (10/2022 - 12/2017)
4.	Kufner, Vera: 2 articles (10/2022 - 12/2017)
5.	Massoudi, Dawiyat: 2 articles (01/2021 - 09/2014)
6.	Brkljacic, Jelena: 2 articles (12/2017 - 04/2011)
7.	Erjavec, Igor: 2 articles (12/2017 - 04/2011)
8.	Grgurevic, Ivica: 2 articles (12/2017 - 04/2011)
9.	Grgurevic, Lovorka: 2 articles (12/2017 - 04/2011)
10.	Rogic, Dunja: 2 articles (12/2017 - 04/2011)

Related Diseases

1.	Neoplasms (Cancer) 12/30/2022 - "There is no evidence showing that the expression of procollagen C-endopeptidase enhancer (PCOLCE) is associated with human tumors, and pan-cancer analysis is not available. " 12/30/2022 - "A pan-cancer analysis of the oncogenic role of procollagen C-endopeptidase enhancer (PCOLCE) in human." 01/01/2022 - "This research explores the underlying link between diagnosis and therapy between bone morphogenetic protein 1 (BMP1) and various cancers. " 01/01/2009 - "The objective of this study was to analyze the three alternatively spliced variants of the BMP1 gene product including the procollagen C-endopeptidase, in leiomyoma uteri tumors in comparison to normal myometrium in women being in first or second menstrual phase or in time of climacterium. " 12/01/2023 - "Similar to other omics studies of cancer, a weak overlap was observed between transcriptome and proteome, and Procollagen C-Endopeptidase Enhancer 2 (PCOLCE2) was observed to be upregulated at mRNA and protein levels. "
2.	Osteoporosis 04/01/2022 - "The aim of this study was assessing the mechanism of nanometric bone pulp activated with double gene as bone morphogenetic protein 1 (BMP-1) and vascular endothelial growth factor (VEGF) in improving the strength of centrum in osteoporosis (OP). " 04/01/2022 - "Research on Mechanism of Nanometric Bone Pulp Activated with Double Gene as Bone Morphogenetic Protein 1 and Vascular Endothelial Growth Factor for Improving the Strength of Centrum in Osteoporosis."
3.	Leiomyoma (Uterine Fibroids) 01/01/2009 - "[Changes of mRNAs encoding alternatively spliced variants of procollagen C-endopeptidase in leiomyomas uteri depending on the phase of menstrual cycle and in postmenopausal women]." 01/01/2009 - "The objective of this study was to analyze the three alternatively spliced variants of the BMP1 gene product including the procollagen C-endopeptidase, in leiomyoma uteri tumors in comparison to normal myometrium in women being in first or second menstrual phase or in time of climacterium. " 01/01/2009 - "Regulation of alternative splicing of mRNA for procollagen C-endopeptidase in leiomyomas and myometrium depends mainly on the hormonal status of women."
4.	Iron-Refractory Iron Deficiency Anemia 01/01/2020 - "Nevertheless, studies of a murine iron-refractory iron-deficiency anemia-causing mutant (Mt2I286F) in the complement protein subcomponents C1r/C1s, urchin embryonic growth factor, and bone morphogenetic protein 1 domain indicate that Mt2I286F can be activated, but it exhibited a largely compromised ability to suppress hepcidin expression. "
5.	Fibrosis (Cirrhosis) 01/01/2016 - "The protein product of the gene most strongly correlated with the fibrosis phenotype PCOLCE (Procollagen C-Endopeptidase Enhancer) was dose-dependently elevated in plasma from animals administered fibrogenic chemicals (P < .05). " 04/01/2011 - "Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis." 10/01/2022 - "Starting from the evidence that a specific isoform of the Bone Morphogenetic Protein 1 (BMP1.3) is particularly elevated in both patients and animal models of myocardial infarction, here we assess whether its inhibition by a specific monoclonal antibody reduces cardiac fibrosis. " 12/01/2019 - "Taken together, these findings indicate that the bone morphogenetic protein 1 inhibitor UK383,367 could serve as a potential drug in antagonizing CKD renal fibrosis by acting on the maturation and deposition of collagen and the subsequent profibrotic response and inflammation." 07/12/2018 - "Bone Morphogenetic Protein 1 (BMP1) inhibition is a potential method for treating fibrosis because BMP1, a member of the zinc metalloprotease family, is required to convert pro-collagen to collagen. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Intercellular Signaling Peptides and Proteins (Growth Factors)
3.	Messenger RNA (mRNA)
4.	Complement System Proteins (Complement)
5.	Hepcidins
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	Proteome
8.	Peptide Hydrolases (Proteases)
9.	Collagen
10.	Protein Isoforms (Isoforms)

Related Therapies and Procedures

1.	Therapeutics