Laminin (Merosin)

Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.

Also Known As:

Networked: 3768 relevant articles (51 outcomes, 446 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hashimoto, Takashi: 20 articles (10/2015 - 02/2009)
2.	Durbeej, Madeleine: 17 articles (11/2014 - 08/2004)
3.	Virtanen, Ismo: 15 articles (06/2014 - 06/2002)
4.	Muntoni, F: 13 articles (07/2005 - 01/2000)
5.	Koga, Hiroshi: 12 articles (10/2015 - 02/2009)
6.	Campbell, Kevin P: 12 articles (07/2015 - 07/2004)
7.	Ishii, Norito: 10 articles (10/2015 - 02/2009)
8.	Miyazaki, Kaoru: 10 articles (06/2015 - 06/2002)
9.	Tryggvason, Karl: 10 articles (01/2014 - 02/2002)
10.	Bissell, Mina J: 10 articles (04/2011 - 01/2002)

Related Diseases

1.	Neoplasms (Cancer) 09/01/1990 - "Immunohistochemical staining for laminin may be helpful in detecting the microinvasion and micrometastasis of cancers." 01/01/1989 - "In summary, our results show that the blockage or modulation of cell surface laminin binding components could be directly correlated with the sensitivity of tumor target cells to be eliminated by way of natural cytotoxicity." 09/01/2014 - "THIRTY CASES OF ACC WERE SUBJECTED TO IMMUNOHISTOCHEMICAL STUDY USING POLYCLONAL ANTIHUMAN LAMININ PRIMARY ANTIBODY, DISTRIBUTION OF LAMININ IN EACH CASE OF ACC WAS OBSERVED IN THE FOLLOWING AREAS: Intracellularly, inner borders of the pseudocystic spaces, within the lumen of the pseudocysts, around the tumor islands and in the intervening stroma. " 09/01/2014 - "Several studies in cancers have shown the importance of LAMC2, a laminin component. " 06/01/2014 - "In the present study, we examined ten mAbs to human laminin α4 chain for their reactivity with the isolated laminin α4 globular domain, their ability to inhibit tumor cell adhesion and migration on laminins 411 and 421, and their effect on the binding of α6β1 integrin and MCAM to both α4-laminins. "
2.	Fibrosis (Cirrhosis) 11/01/2014 - "The treatment completely blocked glomerular fibrosis, as determined by altered mesangial expansion and deposition of laminin. " 02/01/2010 - "Although null mutations in the majority of laminin chains lead to specific developmental abnormalities in the kidney, Lama4-/- mice have progressive glomerular and tubulointerstitial fibrosis. " 05/01/2005 - "When compared with the criteria of Ratziu et al. for the diagnosis of septal fibrosis, laminin values presented a better diagnostic accuracy (83 vs 70%). " 07/01/2003 - "The circulating laminin was correlated to the degree of hepatic fibrosis (rs = 0.59; n = 49) and to portal pressure (r = 0.29; n = 45). " 07/01/2003 - "Peripheral blood laminin concentration in cirrhosis (40.0 +/- 18.7 mg/dL) was significantly higher when compared to control (13.8 +/- 12.1 mg/dL), perivenular fibrosis (19.1 +/- 15.5 mg/dL) and septal fibrosis (22.2 +/- 27.0 mg/dL) groups. "
3.	Carcinoma (Carcinomatosis) 09/01/1995 - "Blockage of the expression or function of alpha 6 beta 1 or laminin or preventing the loss of beta 4 would be essential steps in confining the carcinoma to the prostate gland where conventional treatment has already proven effective." 04/01/2001 - "Patients with laminin gamma(2) chain-positive carcinoma had a significantly shorter disease-free and overall survival time than did those with laminin gamma(2) chain-negative carcinoma. " 07/01/2015 - "We present the first comprehensive study of promoter methylation status of the genes encoding laminin chains in normal tissues (peripheral blood leucocytes, buccal epithelial cells, autopsy breast tissue samples) and in breast carcinoma samples. " 01/01/2008 - "We now extended our studies to explore a possible association between GP formation and laminin 5gamma2 expression at the invading edge of colonic carcinomas. " 01/01/2008 - "Previous studies have shown the presence of dilated neoplastic glands with cellular gaps called glandular pores (GPs) and laminin 5gamma2 expression at the invading edge of colonic carcinomas. "
4.	Muscular Dystrophies (Muscular Dystrophy) 09/01/2014 - "In this study, we generated transgenic mice that overexpress LARGE (LARGE Tg) and crossed them with dy(2J) mice and fukutin conditional knockout mice, a model for laminin α2-deficient congenital muscular dystrophy (MDC1A) and FCMD, respectively. " 03/01/2003 - "This study provides additional evidence that the amount of laminin alpha2 is most critical for the prevention of muscular dystrophy. " 02/01/2003 - "The purpose of this study was to investigate the presence of cardiac involvement in children with merosin-positive congenital muscular dystrophy. " 10/09/2001 - "Congenital muscular dystrophy with primary partial laminin alpha2 chain deficiency: molecular study." 06/01/2000 - "To investigate the relationship between imaging changes and merosin deficiency we undertook a MRI study in the dy/dy mouse, an animal model for this form of human congenital muscular dystrophy. "
5.	Liver Cirrhosis (Hepatic Cirrhosis) 12/01/2010 - "Laminin participates in regulating immune response in addition to being a biomarker of liver fibrosis. " 04/25/2003 - "Laminin is a basement-membrane protein that increases in liver fibrosis. " 01/01/1998 - "In 23 patients with CP, 38 with liver cirrhosis (LC) and 20 healthy controls we compared the serum patterns of PIIIP, laminin and TGFb and assessed whether in CP these markers are correlated with exocrine and endocrine function. " 11/29/1996 - "[Clinical value of laminin determination in progressive liver cirrhosis]." 11/01/1996 - "Both parameters, especially serum laminin, can be used as prognostic markers in addition to the Child criteria in liver cirrhosis."

Related Drugs and Biologics

1.	Fibronectins (Fibronectin)
2.	Hyaluronic Acid (Hyaluronan)
3.	Collagen Type IV (Type IV Collagen)
4.	Hydroxyproline (4 Hydroxyproline)
5.	Collagen
6.	Collagen Type III (Type III Collagen)
7.	Transforming Growth Factor beta (TGF-beta)
8.	Alanine Transaminase (SGPT)
9.	Collagen Type I (Type I Collagen)
10.	Messenger RNA (mRNA)

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Heterologous Transplantation (Xenotransplantation)
3.	Drug Therapy (Chemotherapy)
4.	Transplantation (Transplant Recipients)
5.	Homologous Transplantation (Allograft)