Abstract | AIM: METHODS: Wistar albino rats (250-300 g) were divided into four groups. A cecal-ascending colon volvulus was created by the intestinal clockwise 720° rotation. At the end of one hour, the bowel was detorsioned. Group I (n = 7) was the sham ( laparotomy) group, Group II (n = 7) the control (no treatment, volvulus or detorsion), Group III (n = 7) (N-acetyl cysteine administered ) , and Group IV (n = 7) ( atorvastatin administered ) group. Blood samples were collected from each group via peripheral veins and centrifuged one hour after detorsion. The parameters of ischemia including malondialdehyde, glutathione peroxidase, catalase, and superoxide dismutase were then observed in the serous fluid. RESULTS:
Malondialdehyde and superoxide dismutase increased in the control group, whereas they were reduced in the Group III and Group IV (p = 0.005; p = 0.008, respectively). The glutathione peroxidase levels revealed no significant differences (p > 0.05), whereas the catalase levels of the group III was higher than in each of the other three groups (p < 0.001). Histopathological evaluation detected reduced lesioning of the organ in the groups which were given atorvastatin and N-acetyl cysteine. CONCLUSION:
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Authors | M Yasar, I Erdi, B Kaya |
Journal | Bratislavske lekarske listy
(Bratisl Lek Listy)
Vol. 119
Issue 3
Pg. 167-174
( 2018)
ISSN: 0006-9248 [Print] Slovakia |
PMID | 29536746
(Publication Type: Journal Article)
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Chemical References |
- Free Radical Scavengers
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Malondialdehyde
- Atorvastatin
- Catalase
- Glutathione Peroxidase
- Superoxide Dismutase
- Acetylcysteine
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Topics |
- Acetylcysteine
(pharmacology)
- Animals
- Atorvastatin
(pharmacology)
- Catalase
(drug effects, metabolism)
- Cecal Diseases
(metabolism, pathology)
- Cecum
(drug effects, metabolism, pathology)
- Disease Models, Animal
- Female
- Free Radical Scavengers
(pharmacology)
- Glutathione Peroxidase
(drug effects, metabolism)
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(pharmacology)
- Intestinal Volvulus
(metabolism, pathology)
- Male
- Malondialdehyde
(metabolism)
- Rats
- Rats, Wistar
- Reperfusion Injury
(metabolism, pathology)
- Superoxide Dismutase
(drug effects, metabolism)
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