[The effect of the biologically active additive epiphamine on antioxidant and NADPH-generating enzymes activity under experimental cerebral ischemia/reperfusion in rats].
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| Abstract |
The effect of biologically active additive with immunomodulator properties epiphamine on the activity of antioxidant (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase) and NADPH-generating (glucose-6-phosphate dehydrogenase, NADP-isocitrate dehydrogenase) enzymes has been investigated at experimental cerebral ischemia/reperfusion in rats. The results obtained indicate epiphamine-induced changes of these enzymes activities towards control values. Changes in the content of lactate, a marker of the pathology development, have also been found in experimental animals under ischemia and epiphamine administration caused changes similar to those observed in the case of enzyme activities studied. In most cases, the changes were dose-dependent. Thus, epiphamine can be of considerable interest from the point of view of metabolic changes pharmacological correction at the development of the pathology accompanied by oxidative stress.
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| Authors | T N Popova, O A Safonova, A O Stolyarova, A N Verevkin |
| Journal | Biomeditsinskaia khimiia (Biomed Khim) Vol. 64 Issue 1 Pg. 31-37 (Jan 2018) ISSN: 2310-6972 [Print] Russia (Federation) |
| Vernacular Title | Vozdeĭstvie BAD épifamin na aktivnost' antioksidantnykh i NADPH-generiruiushchikh fermentov pri éksperimental'noĭ ishemii/reperfuzii golovnogo mozga u krys. |
| PMID | 29460832 (Publication Type: Journal Article) |
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