Association between Fluorescent Advanced Glycation End-Products and Vascular Complications in Type 2 Diabetic Patients.

Abstract

OBJECTIVES:

Diabetes is a major health problem associated with hyperglycemia and chronically increased oxidative stress and enhanced formation of advanced glycation end-products (AGEs). The aim of this study was to determine whether oxidative plasma biomarkers in diabetic patients could be evidenced and associated with vascular complications.

METHODS:

Oxidative stress biomarkers such as thiols, ischemia-modified albumin (IMA), glycated albumin (GA), fructosamine, and AGEs were measured in 75 patients with poorly controlled type 2 diabetes (HbA1c > 7.5%) with (44) or without (31) vascular disease and in 31 nondiabetic controls.

RESULTS:

Most biomarkers of oxidation and glycation were significantly increased in diabetic patients in comparison with nondiabetics. Fructosamines, GA, IMA, and AGEs were positively correlated and levels of fluorescent AGEs were significantly increased in the plasma from patients presenting vascular complication.

CONCLUSIONS:

These results bring new evidence for the potential interest of glycated albumin, oxidative stress, and glycoxidation parameters in the monitoring of type 2 diabetic patients. Furthermore, it emphasizes fluorescent AGEs as a putative indicator for vascular event prediction in diabetic patients.

• Authors: Alexis Guerin-Dubourg, Maxime Cournot, Cynthia Planesse, Xavier Debussche, Olivier Meilhac, Philippe Rondeau, Emmanuel Bourdon
• Journal: BioMed research international (Biomed Res Int) Vol. 2017 Pg. 7989180 ( 2017) ISSN: 2314-6141 [Electronic] United States
• PMID: 29362717 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Biomarkers
• Glycated Hemoglobin A
• Glycation End Products, Advanced
• Serum Albumin
• ischemia-modified albumin
• Fructosamine
• Serum Albumin, Human
• Glycated Serum Albumin

Topics

• Biomarkers (blood, metabolism)
• Cardiovascular Diseases (blood, etiology, metabolism)
• Case-Control Studies
• Diabetes Mellitus, Type 2 (blood, complications, metabolism)
• Female
• Fructosamine (metabolism)
• Glycated Hemoglobin (metabolism)
• Glycation End Products, Advanced (metabolism)
• Humans
• Male
• Middle Aged
• Oxidation-Reduction
• Oxidative Stress (physiology)
• Pilot Projects
• Serum Albumin (metabolism)
• Serum Albumin, Human (metabolism)
• Glycated Serum Albumin