IL-4 driven transcription factor FoxQ1 is expressed by monocytes in atopic dermatitis and stimulates monocyte migration.

Abstract	Monocytes are actively recruited at sites of chronic inflammation. However, molecular factors involved in this process are not fully elucidated. Here, we show that cytokine IL-4 which is implicated in the development of chronic inflammatory disease atopic dermatitis (AD) induces expression of transcription factor FoxQ1 in human monocytes and macrophages. FoxQ1 mRNA levels were elevated in monocytes of AD patients compared to healthy donors. Overexpression of FoxQ1 in RAW 264.7 monocytic cells facilitated their migration towards MCP-1 and was associated with decreased expression of migration-regulating genes (claudin 11 and plexin C1). Furthermore, FoxQ1 overexpression in RAW cells accelerated TNFα secretion after LPS challenge. Overall, our results indicate that FoxQ1 stimulates monocyte motility, increases pro-inflammatory potential, and directs monocyte migration towards MCP-1 that is crucial for monocyte influx into inflammatory sites. This mechanism could contribute to the pathogenesis of chronic inflammatory disorders such as AD.
Authors	Ilja Ovsiy, Vladimir Riabov, Ioannis Manousaridis, Julia Michel, Kondaiah Moganti, Shuiping Yin, Tengfei Liu, Carsten Sticht, Elisabeth Kremmer, Martin C Harmsen, Sergij Goerdt, Alexei Gratchev, Julia Kzhyshkowska
Journal	Scientific reports (Sci Rep) Vol. 7 Issue 1 Pg. 16847 (12 04 2017) ISSN: 2045-2322 [Electronic] England
PMID	29203829 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Chemokine CCL2 Claudins FOXQ1 protein, human Forkhead Transcription Factors Lipopolysaccharides Tumor Necrosis Factor-alpha Interleukin-4
Topics	Adolescent Adult Animals Cell Movement (drug effects) Cells, Cultured Chemokine CCL2 (metabolism) Claudins (metabolism) Dermatitis, Atopic (metabolism, pathology) Forkhead Transcription Factors (genetics, metabolism) Gene Expression Regulation (drug effects) Humans Interleukin-4 (metabolism) Lipopolysaccharides (pharmacology) Macrophages (cytology, drug effects, metabolism) Mice Middle Aged Monocytes (cytology, metabolism) RAW 264.7 Cells Tumor Necrosis Factor-alpha (metabolism) Young Adult

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