Dynamics of liver enzymes in rabbits experimentally infected with Fasciola sp. (Intermediate form from Japan).

Abstract

Dynamics of serum liver enzymes in rabbits experimentally infected with metacercariae of Fasciola sp. (intermediate form between Fasciola hepatica and F. gigantica) were monitored. Gradual increase of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed from 3 weeks post-inoculation (WPI) and peaked at 6 WPI, which corresponded well to the period of migration and development of juvenile fluke in the liver parenchyma and the time when the young adult flukes migrated to the bile duct. However, no significant increase in serum gamma-glutamyl transferase (GGT) and alkaline phosphatase (ALP) were observed. This could reflect reduced or minimal injury of bile ducts and biliary epithelia as the flukes had reached the adult stage. Alpha- fetoprotein (AFP) and carcinoembryonic antigen (CEA) were not detected in the infected rabbit during the course of the experiment. Serum liver enzymes monitoring might be useful for understanding the host-parasite relationship in fascioliasis.

• Authors: Wipaporn Jarujareet, Kensuke Taira, Hong Kean Ooi
• Journal: The Journal of veterinary medical science (J Vet Med Sci) Vol. 80 Issue 1 Pg. 36-40 (Jan 01 2018) ISSN: 1347-7439 [Electronic] Japan
• PMID: 29118312 (Publication Type: Journal Article)

Chemical References

• Carcinoembryonic Antigen
• alpha-Fetoproteins
• gamma-Glutamyltransferase
• Aspartate Aminotransferases
• Alanine Transaminase
• Alkaline Phosphatase

Topics

• Alanine Transaminase (blood)
• Alkaline Phosphatase (blood)
• Animals
• Aspartate Aminotransferases (blood)
• Bile Ducts (parasitology)
• Carcinoembryonic Antigen (blood)
• Fasciola
• Fascioliasis (enzymology, veterinary)
• Japan
• Liver (enzymology, parasitology)
• Parasite Egg Count (veterinary)
• Rabbits (parasitology)
• alpha-Fetoproteins (analysis)
• gamma-Glutamyltransferase (blood)