Abstract |
The exploration of electroactive labelling with tailorable and strong differential pulse voltammetry (DPV) responses is of great importance in accurate and sensitive screening of a panel of biomarkers related to cancer. Herein, shell-encoded gold nanoparticles (Au NPs) are fabricated and give rise to shell species-dominated DPV peak potentials. Two independent DPV peaks appear at -0.08V for Au@Cu2O core-shell NPs and 0.26V for Au@Ag core-shell NPs. Shell-encoded Au NPs drastically exhibit shell thickness-tunable amplified peak currents. The non-interfering and amplified DPV responses enable shell-encoded Au NPs to be an alternative electrochemical signal amplifier for dual screening of carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP). The limits of detection (LODs) are calculated to be 1.8pg/mL for CEA and 0.3pg/mL for AFP. In comparison to the parallel single-analyte assays, shell-encoded Au NPs engineered electrochemical aptasensors offer multiplexing capability and show significant prospects in biomedical research and early diagnosis of diseases.
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Authors | Yuan Zhao, Yaxin Yang, Yali Sun, Linyan Cui, Fangjie Zheng, Jiru Zhang, Qijun Song, Chuanlai Xu |
Journal | Biosensors & bioelectronics
(Biosens Bioelectron)
Vol. 99
Pg. 193-200
(Jan 15 2018)
ISSN: 1873-4235 [Electronic] England |
PMID | 28759869
(Publication Type: Journal Article)
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Copyright | Copyright © 2017. Published by Elsevier B.V. |
Chemical References |
- Carcinoembryonic Antigen
- alpha-Fetoproteins
- Gold
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Topics |
- Biosensing Techniques
- Carcinoembryonic Antigen
(genetics, isolation & purification)
- Early Diagnosis
- Gold
(chemistry)
- Humans
- Limit of Detection
- Metal Nanoparticles
(chemistry)
- alpha-Fetoproteins
(genetics, isolation & purification)
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