Abstract | BACKGROUND AND PURPOSE: EXPERIMENTAL APPROACH: Visceral sensitivity (visceromotor response) was monitored by measuring the electrical activity of the abdominal external oblique muscle contraction in response to CRD using a barostat apparatus. Visceral hypersensitivity was induced by a colonic instillation of sodium butyrate or acetic acid in neonates. KEY RESULTS:
Oral administration of chlorpromazine suppressed butyrate-induced visceral hypersensitivity to CRD. Interestingly, atypical antipsychotic drugs, quetiapine and risperidone, ameliorated butyrate-induced visceral hypersensitivity, whereas the typical antipsychotic drugs, haloperidol and sulpiride, did not. Pharmacological analysis using specific inhibitors showed that a selective 5-HT2A receptor antagonist, ketanserin, suppressed butyrate-induced visceral hypersensitivity, whereas a selective dopamine D2 receptor antagonist, L-741626, did not. Furthermore, the 5-HT2A receptor agonist AL-34662 stimulated visceral sensitivity to CRD in healthy control rats but not in butyrate-treated rats. These findings suggest that increased 5-HT levels in the colon contribute to the induction of visceral hypersensitivity. CONCLUSIONS AND IMPLICATIONS:
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Authors | Teita Asano, Ken-Ichiro Tanaka, Arisa Tada, Hikaru Shimamura, Rikako Tanaka, Hiroki Maruoka, Tohru Mizushima, Mitsuko Takenaga |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 174
Issue 19
Pg. 3370-3381
(Oct 2017)
ISSN: 1476-5381 [Electronic] England |
PMID | 28750135
(Publication Type: Journal Article)
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Copyright | © 2017 The British Pharmacological Society. |
Chemical References |
- Antipsychotic Agents
- Receptor, Serotonin, 5-HT2A
- Serotonin 5-HT2 Receptor Antagonists
- Butyric Acid
- Serotonin
- Acetic Acid
- Chlorpromazine
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Topics |
- Acetic Acid
- Animals
- Antipsychotic Agents
(pharmacology, therapeutic use)
- Butyric Acid
- Chlorpromazine
(pharmacology, therapeutic use)
- Colon
(drug effects, metabolism)
- Ganglia, Spinal
(drug effects, metabolism)
- MAP Kinase Signaling System
(drug effects)
- Male
- Rats, Wistar
- Receptor, Serotonin, 5-HT2A
(metabolism)
- Serotonin
(metabolism)
- Serotonin 5-HT2 Receptor Antagonists
(pharmacology, therapeutic use)
- Visceral Pain
(chemically induced, drug therapy, metabolism)
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