Chlorpromazine (Thorazine)

The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.

Also Known As:

Networked: 2471 relevant articles (110 outcomes, 200 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	He, Lin: 6 articles (08/2010 - 03/2005)
2.	Leucht, Stefan: 4 articles (11/2015 - 01/2014)
3.	Adams, Clive E: 4 articles (01/2014 - 07/2007)
4.	Guo, Xiaofeng: 4 articles (10/2012 - 09/2009)
5.	Fang, Maosheng: 4 articles (10/2012 - 09/2009)
6.	Zhao, Jingping: 4 articles (10/2012 - 09/2009)
7.	Adams, C E: 4 articles (01/2007 - 01/2000)
8.	Si, Tian-Mei: 3 articles (04/2014 - 11/2011)
9.	Shinfuku, Naotaka: 3 articles (04/2014 - 01/2009)
10.	Sartorius, Norman: 3 articles (04/2014 - 01/2009)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 03/07/2005 - "Our results show that genotyping -141C Ins/Del may help to predict the efficacy of chlorpromazine treatment (P=0.01) due to the fact that patients with no Del allele showed greater improvement than those with Del allele on the overall BPRS (P=0.03), and that, therefore, the potential for therapy in patients with schizophrenia is related to the -141C Ins/Del polymorphism in the DRD2 gene. " 04/01/1962 - "Relative efficacy of electroconvulsive therapy and chlorpromazine in schizophrenia." 07/01/2014 - "We therefore conducted a meta-analysis of randomised controlled trials on the efficacy of chlorpromazine versus any other antipsychotic in the treatment of schizophrenia. " 04/01/2014 - "This study aimed to examine the use of high doses of antipsychotic medications (≥600 mg/day chlorpromazine equivalent) in older Asian patients with schizophrenia and its demographic and clinical correlates. " 01/01/2014 - "We included all randomised controlled trials (RCTs) comparing chlorpromazine with placebo for people with schizophrenia and non-affective serious/chronic mental illness irrespective of mode of diagnosis. "
2.	Vomiting 09/01/1954 - "Thorazine was very effective in the control of vomiting, regardless of cause, in 20 cases in which it was used. " 01/01/1988 - "In the trial described in this report, i.v. DON therapy was studied, using i.v. chlorpromazine to control vomiting, in 20 children, 17 of whom were evaluable following treatment at DON dose levels ranging from 150 mg/m2 to 520 mg/m2. " 06/01/1982 - "Effectiveness of the chlorpromazine was determined by comparing oral therapy failure rates, purging rates, vomiting rates, i.v. fluid requirements and hospitalization time in groups of the patients receiving and not receiving the drug. " 05/08/1982 - "Chlorpromazine also significantly reduced the duration of diarrhoea, frequency of vomiting, and amount of intravenous fluid required. " 05/24/1958 - "[Use of chlorpromazine in the treatment of vomiting caused by methyl-bis-(beta-chlorethyl)amine]."
3.	Migraine Disorders (Migraine) 12/01/1983 - "A prospective, uncontrolled clinical trial was conducted to test the safety and efficacy of intramuscular chlorpromazine (1 mg/kg) in the acute, outpatient treatment of migraine. " 04/01/2014 - "This study showed that intra-venous chlorpromazine with fluid treatment for status migrainosus seems a good option." 02/01/2014 - "This is the first study that has examined the use of chlorpromazine as a therapy in pediatric migraines. " 04/01/2014 - "Consecutive 21 patients with status migrainosus were received intra-venous chlorpromazine (maximum 25mg) with fluid treatment and their results were documented. " 04/01/2014 - "To present the results of the intra-venous chlorpromazine with fluid treatment in patients with status migrainosus. "
4.	Pain (Aches) 09/01/2002 - "Patients receiving chlorpromazine showed a statistically significant improvement (p < 0.05 and p < 0.01) of pain compared to placebo, far up to 30 minutes after the drug administration. " 06/01/2002 - "Retrobulbar chlorpromazine appears to be safe and effective for the management of pain in blind eyes." 02/01/2012 - "A double-blind controlled trial, published in 1980, showed that chlorpromazine increased slow-wave sleep and improved pain and mood disturbances. " 05/01/2012 - "An 80-year-old woman with a painful, poorly seeing right eye underwent retrobulbar chlorpromazine injection for pain control. " 01/01/2011 - "In the pain test, chlorpromazine did not alter tail flick latency but decreased hind paw lick latency in the hot plate at 2.0 and 4.0 mg/kg (p< 0.01), indicating increased pain sensitivity at these doses which may indirectly increase social withdrawal and thus aggravating depression. "
5.	Neoplasms (Cancer) 05/01/2012 - "Intravenous chlorpromazine is safe and effective for procedural sedation in young children with cancer undergoing MRI and CT." 05/01/2012 - "To assess the efficacy and safety of intravenous chlorpromazine sedation for repeated imaging in young children treated for cancer. " 12/01/2011 - "Chlorpromazine has activity against a large variety of cancer types. " 11/01/2002 - "The administration of chlorpromazine hydrochloride at dose levels up to and including 10 mg/kg to p53 heterozygous and wild-type mice did not result in a dose-related increase in tumor incidence or in the type of tumors seen in comparison to controls. " 09/01/1998 - "A randomized prospective study was conducted to evaluate the effectiveness of chlorpromazine as a sensitizer of radiation in advanced head and neck cancers. "

Related Drugs and Biologics

1.	Metoclopramide (Reglan)
2.	Promethazine (Promet)
3.	Clozapine (Clozaril)
4.	Haloperidol (Haldol)
5.	Antipsychotic Agents (Antipsychotics)
6.	Dexamethasone (Maxidex)
7.	Reserpine (Serpasil)
8.	Lorazepam (Ativan)
9.	olanzapine (Zyprexa)
10.	Diazepam (Valium)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intravenous Injections
3.	Aftercare (After-Treatment)
4.	Intravenous Infusions
5.	Peritoneal Dialysis