Agrin to YAP in Cancer and Neuromuscular Junctions.

Abstract

Agrin is utilized by motor neurons to stimulate the LRP4-MuSK receptor in muscles for neuromuscular junction (NMJ) formation. Recent studies of cancer have identified novel functions of the low-density lipoprotein receptor-related protein 4-muscle-specific kinase (LRP4-MuSK) pathway. Agrin may act as a mechanotransduction signal in the extracellular matrix (ECM) to coordinate the cross-talk between the LRP4-MuSK pathway and integrin-focal adhesion pathway. Ensuing Yes-associated protein (YAP) activation promotes hepatocellular carcinoma (HCC). Here, we discuss the implications of the converged pathways in NMJ formation and liver cancer.

• Authors: Wen-Cheng Xiong, Lin Mei
• Journal: Trends in cancer (Trends Cancer) Vol. 3 Issue 4 Pg. 247-248 (04 2017) ISSN: 2405-8025 [Electronic] United States
• PMID: 28718435 (Publication Type: Journal Article, Comment)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Adaptor Proteins, Signal Transducing
• Agrin
• Cell Cycle Proteins
• Phosphoproteins
• YAP-Signaling Proteins
• Yap1 protein, mouse

Topics

• Adaptor Proteins, Signal Transducing (metabolism)
• Agrin (metabolism)
• Animals
• Cell Cycle Proteins
• Humans
• Mice
• Neuromuscular Junction (metabolism)
• Phosphoproteins (metabolism)
• Signal Transduction
• YAP-Signaling Proteins