Attenuation of Diabetes-induced Cardiac and Subcellular Defects by Sulphur-containing Amino Acids.

Abstract

BACKGROUND:

Patients with diabetes mellitus have an increased risk of mortality due to cardiovascular complications. Supplementation with specific sulphur-containing amino acids is rapidly emerging as a possible therapeutic adjuvant for diabetes and associated cardiovascular complications.

OBSERVATIONS:

It is well-known that oxidative stress plays an important role in the pathogenesis of diabetes-induced cardiovascular disease, which is invariably associated with abnormal blood lipid profile, insulin resistance and other symptoms of metabolic syndrome. Cysteine and taurine are among the most common sulphur-containing amino acids and their cellular levels decline during diabetes that may contribute to the development of the cardiomyopathy. Although sulphur-containing agents exert multiple actions on cellular and subcellular functions in the heart, they also exhibit antioxidant properties and thus may exert beneficial effects in different pathophysiological conditions.

CONCLUSION:

It is concluded that reduction of oxidative stress by cysteine and taurine may serve as an important mechanism for the attenuation of diabetes-induced subcellular and functional abnormalities in the heart.

• Authors: Paramjit S Tappia, Adriana Adameova, Naranjan S Dhalla
• Journal: Current medicinal chemistry (Curr Med Chem) Vol. 25 Issue 3 Pg. 336-345 (Jan 30 2018) ISSN: 1875-533X [Electronic] United Arab Emirates
• PMID: 28685680 (Publication Type: Journal Article, Review)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Amino Acids
• Antioxidants
• Sulfur

Topics

• Amino Acids (pharmacology)
• Animals
• Antioxidants (pharmacology)
• Diabetes Mellitus (metabolism, physiopathology)
• Diabetic Cardiomyopathies (complications, drug therapy, physiopathology)
• Humans
• Oxidative Stress (drug effects)
• Sulfur (pharmacology)