Abstract | PURPOSE OF REVIEW:
Kawasaki disease is an acute multisystem childhood vasculitis with a predilection for the coronary arteries. The role of corticosteroids and acetyl salicylic acid (ASA) in the treatment of acute Kawasaki disease are matters of ongoing debate and changing attitudes from one extreme to the other. Recent work has provided new evidence to guide our thinking about these two therapeutic agents, which will be the focus of this review. RECENT FINDINGS: SUMMARY:
Corticosteroids should be used in patients at high-risk for poor coronary outcome, and in patients who fail IVIG. The absence of widely applicable and validated risk-scoring systems in Kawasaki disease outside of Japan remains a limiting factor to identify high-risk children. Current evidence does not demonstrate any advantage of high-dose over low-dose ASA in the acute phase of Kawasaki disease, in preventing coronary artery aneurysms.
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Authors | Anita Dhanrajani, Rae S M Yeung |
Journal | Current opinion in rheumatology
(Curr Opin Rheumatol)
Vol. 29
Issue 5
Pg. 547-552
(Sep 2017)
ISSN: 1531-6963 [Electronic] United States |
PMID | 28661936
(Publication Type: Journal Article, Review)
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Chemical References |
- Adrenal Cortex Hormones
- Anti-Inflammatory Agents, Non-Steroidal
- Immunoglobulins, Intravenous
- Aspirin
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Topics |
- Adrenal Cortex Hormones
(therapeutic use)
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Aspirin
(therapeutic use)
- Child
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Mucocutaneous Lymph Node Syndrome
(drug therapy)
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