Understanding the Role of Photolyases: Photoprotection and Beyond.

Abstract

The limitations of photoprotection modalities have been the inability to arrest the progression of photodamage. Chemoprevention strategies involving a sunscreen has been incomplete because of the need to induce sustained repair of mutations and slow carcinogenesis. Photolyases, or photoreactivation enzymes, serve the role of repairing mutations and damage to DNA induced by ultraviolet (UV) radiation and therefore influence the initiation phases of carcinogenesis. As these enzymes are absent in humans, exogenous forms have been manufactured and are now utilized in topical agents to supplement and augment the innate repair mechanisms that are mostly inefficient. J Drugs Dermatol. 2017;16(5 Suppl):61-66.

• Authors: Neal Bhatia, Brian Berman, Roger I Ceilley, Leon H Kircik
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 16 Issue 5 Pg. 61-66 (05 01 2017) ISSN: 1545-9616 [Print] United States
• PMID: 28628693 (Publication Type: Journal Article, Review)

Chemical References

• Sunscreening Agents
• Deoxyribodipyrimidine Photo-Lyase

Topics

• Animals
• DNA Damage (drug effects, physiology)
• Deoxyribodipyrimidine Photo-Lyase (antagonists & inhibitors, physiology)
• Humans
• Skin Neoplasms (genetics, pathology, prevention & control)
• Sunscreening Agents (administration & dosage, chemistry)
• Ultraviolet Rays (adverse effects)