GalNAc-T6 in the relationship with invasion ability of endometrial carcinomas and prognostic significance.

Abstract

O-glycosylation in the field of carcinogenesis has been a critical topic of concern for several decades. The abnormal function of enzymes catalyzing the first step of this process, named polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) has been determined to play an important role in cancer development and metastasis. Accordingly, we investigated the expression of GalNAc-T6 in endometrial carcinoma and evaluated the relationship between invasion characteristics and the cellular level of GalNAc-T6. The results suggested that positive GalNAc-T6 expression is significantly associated with histological grade of tumors and myometrial invasion characteristic. In vitro experiments showed that the over expression of GalNAc-T6 had strong association with the decrease of endometrial cell invasiveness. Taken together, our data support the use of GalNAc-T6 as a potential indicator of good prognosis and noninvasive tumor in patients with endometrial carcinoma.

• Authors: Thuy Thi Nguyen, Tomoko Kurita, Chiho Koi, Midori Murakami, Seiji Kagami, Toru Hachisuga, Hisaoka Masanori, Yasuo Morimoto, Hiroto Izumi
• Journal: American journal of cancer research (Am J Cancer Res) Vol. 7 Issue 5 Pg. 1188-1197 ( 2017) ISSN: 2156-6976 [Print] United States
• PMID: 28560066 (Publication Type: Journal Article)