Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice.

Abstract

SCOPE:

Ginger exerts protective effects on obesity and its complications. Our objectives here are to identify bioactive compounds that inhibit adipogenesis and lipid accumulation in vitro, elucidate the anti-obesity effect of gingerenone A (GA) in diet-induced obesity (DIO), and investigate whether GA affects adipose tissue inflammation (ATI).

METHODS AND RESULTS:

Oil red O staining showed that GA had the most potent inhibitory effect on adipogenesis and lipid accumulation in 3T3-L1 cells among ginger components tested at a single concentration (40 μM). Consistent with in vitro data, GA attenuates DIO by reducing fat mass in mice. This was accompanied by a modulation of fatty acid metabolism via activation of AMP-activated protein kinase (AMPK) in vitro and in vivo. Additionally, GA suppressed ATI by inhibiting macrophage recruitment and downregulating pro-inflammatory cytokines.

CONCLUSION:

These results suggest that GA may be used as a potential therapeutic candidate for the treatment of obesity and its complications by suppressing adipose expansion and inflammation.

• Authors: Sujin Suk, Gyoo Taik Kwon, Eunjung Lee, Woo Jung Jang, Hee Yang, Jong Hun Kim, N R Thimmegowda, Min-Yu Chung, Jung Yeon Kwon, Seunghee Yang, Jason K Kim, Jung Han Yoon Park, Ki Won Lee
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 61 Issue 10 (10 2017) ISSN: 1613-4133 [Electronic] Germany
• PMID: 28556482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Anti-Obesity Agents
• Ccl2 protein, mouse
• Chemokine CCL2
• Diarylheptanoids
• Fatty Acids, Nonesterified
• Polyphenols
• Triglycerides
• gingerenone A
• Cholesterol
• AMP-Activated Protein Kinases

Topics

• 3T3-L1 Cells
• AMP-Activated Protein Kinases (genetics, metabolism)
• Adipocytes (cytology, drug effects)
• Adipogenesis (drug effects)
• Adiposity (drug effects)
• Animals
• Anti-Obesity Agents (pharmacology)
• Chemokine CCL2 (genetics, metabolism)
• Cholesterol (blood)
• Coculture Techniques
• Diarylheptanoids (pharmacology)
• Diet, High-Fat
• Fatty Acids, Nonesterified (blood)
• Gene Expression Regulation
• Ginger (chemistry)
• Inflammation (drug therapy)
• Lipid Metabolism (drug effects)
• Male
• Mice
• Mice, Inbred C57BL
• Obesity (drug therapy)
• Polyphenols (pharmacology)
• RAW 264.7 Cells
• Triglycerides (blood)