Abstract | CONTEXT: OBJECTIVE: DESIGN: Cross-sectional study involving six diabetes outpatient clinics in Sweden. PATIENTS: were enrolled individuals with type 2 diabetes between February 2008 and December 2013. MEASUREMENTS: Plasma aldosterone concentrations (PAC pmol/L) and direct renin concentrations (DRC mIU/L) were measured. Patients with increased aldosterone renin ratios (ARR) >65 were further evaluated for PA. RESULTS: Of 578 consecutively screened patients with type 2 diabetes, 27 were treated with mineralocorticoid receptor antagonists (MRA) and potassium-sparing diuretics not further evaluated. Among the remaining 551 patients, 38 had increased ARR, including 22 who were clinically indicated for PA tests and 16 who were not further evaluated due to severe comorbidities and old age. There were five (0.93%) patients with confirmed PA after computerized tomography and adrenal venous sampling. Patients with PA had higher systolic blood pressure (P=.032) and lower potassium levels (P=.027) than those without PA. No significant association was found between plasma aldosterone and diabetic complications. CONCLUSIONS:
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Authors | Mauro Tancredi, Gudmundur Johannsson, Björn Eliasson, Robert Eggertsen, Ulf Lindblad, Sofia Dahlqvist, Henrik Imberg, Marcus Lind |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 87
Issue 3
Pg. 233-241
(Sep 2017)
ISSN: 1365-2265 [Electronic] England |
PMID | 28493291
(Publication Type: Journal Article, Multicenter Study)
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Copyright | © 2017 John Wiley & Sons Ltd. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Aldosterone
(blood)
- Blood Pressure
- Cross-Sectional Studies
- Diabetes Mellitus, Type 2
(complications)
- Female
- Humans
- Hyperaldosteronism
(complications, epidemiology)
- Hypokalemia
- Male
- Middle Aged
- Prevalence
- Sweden
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