Abstract | BACKGROUND:
Allergic rhinitis (AR) is a heterogeneous disorder that significantly affects daily activity, work productivity, sleep, learning, and quality of life in all generations. Japanese cedar (JC) pollen is the most common allergen responsible for the development of AR in Japan. AR caused by JC pollen is considered to be a multifactorial inheritance disease that is caused by both environmental and genetic factors. The aim of this study was to investigate whether Human Leukocyte Antigen-DPB1 (HLA-DPB1) is associated with JC sensitization/ pollinosis. METHODS: Subjects in the present study were 544 students at the University of Tsukuba from 2013 to 2015. PCR-SSOP was performed to determine each individual's HLA-DPB1 alleles. Logistic regression analysis was performed to examine relationships between JC-related phenotypes and alleles/ amino acid polymorphisms of HLA-DPB1. RESULTS: CONCLUSIONS:
Amino acid changes in the allergen-binding pocket of HLA-DPβ1 are likely to influence pollinosis/sensitization to the allergenic peptide of JC pollen and determine the pollinosis risk for each individual exposed to JC pollen.
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Authors | Wataru Morii, Aiko Sakai, Takahiro Ninomiya, Masanori Kidoguchi, Ryo Sumazaki, Shigeharu Fujieda, Emiko Noguchi |
Journal | Allergology international : official journal of the Japanese Society of Allergology
(Allergol Int)
Vol. 67
Issue 1
Pg. 61-66
(Jan 2018)
ISSN: 1440-1592 [Electronic] England |
PMID | 28460831
(Publication Type: Clinical Trial, Journal Article)
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Copyright | Copyright © 2017 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved. |
Chemical References |
- Allergens
- HLA-DP beta-Chains
- HLA-DPB1 antigen
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Topics |
- Adolescent
- Adult
- Allergens
(immunology)
- Cedrus
- Genetic Predisposition to Disease
- HLA-DP beta-Chains
(genetics, immunology)
- Humans
- Japan
- Pollen
(immunology)
- Rhinitis, Allergic, Seasonal
(epidemiology, genetics, immunology)
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