Hypothyroidism in Pediatric Population - Bosnian and Herzegovinian Situation.

Abstract

INTRODUCTION:

Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages.

GOAL:

To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality.

PATIENTS AND METHODS:

The study have retrospective character and includes all patients who have the diagnosis of hypothyroidism, but at the moment of data collection were aged 0-18 years.

RESULTS:

Distribution of patients on the basis of gender, revealed more significant representation of female (65.93%), and without significant difference in the presence of the disease in relation to age (p>0.05). Physical examination of the struma was not verified in the majority of cases (74; 81.32%, p<0.05) suffering from hypothyroidism. Ultrasound review in 22 (50%) cases confirmed the struma. Ultrasound findings in most cases 14 (31.81%) demonstrated diffuse struma and Hashimoto thyroiditis together. In relation to the etiology of hypothyroidism most patients belong to a group where hypothyroidism is associated with other diseases and conditions (27; 29.67%), but the least with congenital hypothyroidism with 18 (19.78%) cases. The average dose of L-thyroxine in the age of 0-1 months was 50 mg, 1 month-10 years 37.5 mcg, and the group of patients over 10 years 65 mcg.

CONCLUSION:

Congenital hypothyroidism has about one-fifth of patients. Physical examination revealed in about one fifth of patients the struma of the thyroid gland; TSH levels is critical for the diagnosis and correction of therapy in pediatric patients with hypothyroidism. Congenital hypothyroidism is diagnosed on average at the age of 12 days, which is optimal for period for therapeutic response; Substitution treatment is carried out with L-thyroxine which is relatively reduced in doses from neonatal age onwards.

• Authors: Edo Hasanbegovic, Snijezana Hasanbegovic, Edin Begic
• Journal: Medical archives (Sarajevo, Bosnia and Herzegovina) (Med Arch) Vol. 71 Issue 1 Pg. 62-65 (Feb 2017) ISSN: 0350-199X [Print] Bosnia and Herzegovina
• PMID: 28428677 (Publication Type: Journal Article)

Chemical References

• Thyroxine

Topics

• Adolescent
• Bosnia and Herzegovina (epidemiology)
• Child
• Child, Preschool
• Congenital Hypothyroidism (diagnosis, drug therapy, epidemiology)
• Dose-Response Relationship, Drug
• Female
• Hashimoto Disease (epidemiology)
• Humans
• Infant
• Infant, Newborn
• Male
• Physical Examination
• Retrospective Studies
• Thyroid Function Tests
• Thyroid Gland (diagnostic imaging, pathology)
• Thyroxine (therapeutic use)
• Ultrasonography