Raised cerebrospinal fluid BAFF and APRIL levels in anti-N-methyl-d-aspartate receptor encephalitis: Correlation with clinical outcome.

Abstract

In this study, we aimed to assess the levels of B cell activating factor from the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) in cerebrospinal fluid (CSF) of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis and determine their correlation with clinical outcome. BAFF and APRIL concentrations in CSF and serum from 40 patients with anti-NMDAR encephalitis and 20 controls were measured by enzyme-linked immunosorbent assay (ELISA). Compared with controls, the levels of both BAFF and APRIL in CSF were significantly increased in patients with anti-NMDAR encephalitis (p<0.001 and p<0.001). Patients with unfavorable outcome had higher levels of BAFF and APRIL in CSF than those who had favorable outcome (p<0.05 and p<0.05). BAFF and APRIL levels in CSF were elevated and associated with clinical outcome in patients with anti-NMDAR encephalitis, indicating that they may be valuable biomarkers to this disease.

• Authors: Bo Deng, Xiao-Ni Liu, Xiang Li, Xiang Zhang, Chao Quan, Xiang-Jun Chen
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 305 Pg. 84-91 (04 15 2017) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 28284352 (Publication Type: Journal Article)
• Copyright: Copyright © 2017 Elsevier B.V. All rights reserved.

Chemical References

• B-Cell Activating Factor
• TNFSF13B protein, human
• Tumor Necrosis Factor Ligand Superfamily Member 13

Topics

• Adolescent
• Adult
• Anti-N-Methyl-D-Aspartate Receptor Encephalitis (cerebrospinal fluid, complications)
• B-Cell Activating Factor (cerebrospinal fluid)
• Enzyme-Linked Immunosorbent Assay
• Female
• Humans
• Longitudinal Studies
• Male
• Middle Aged
• Ovarian Neoplasms (complications)
• Retrospective Studies
• Severity of Illness Index
• Statistics as Topic
• Tumor Necrosis Factor Ligand Superfamily Member 13 (cerebrospinal fluid)
• Young Adult