Biomarkers associated with sedentary behaviour in older adults: A systematic review.

Abstract

OBJECTIVE:

Pathomechanisms of sedentary behaviour (SB) are unclear. We conducted a systematic review to investigate the associations between SB and various biomarkers in older adults.

METHODS:

Electronic databases were searched (MEDLINE, EMBASE, CINAHL, AMED) up to July 2015 to identify studies with objective or subjective measures of SB, sample size ≥50, mean age ≥60years and accelerometer wear time ≥3days. Methodological quality was appraised with the CASP tool. The protocol was pre-specified (PROSPERO CRD42015023731).

RESULTS:

12701 abstracts were retrieved, 275 full text articles further explored, from which 249 were excluded. In the final sample (26 articles) a total of 63 biomarkers were detected. Most investigated markers were: body mass index (BMI, n=15), waist circumference (WC, n=15), blood pressure (n=11), triglycerides (n=12) and high density lipoprotein (HDL, n=15). Some inflammation markers were identified such as interleukin-6, C-reactive protein or tumor necrosis factor alpha. There was a lack of renal, muscle or bone biomarkers. Randomized controlled trials found a positive correlation for SB with BMI, neck circumference, fat mass, HbA1C, cholesterol and insulin levels, cohort studies additionally for WC, leptin, C-peptide, ApoA1 and Low density lipoprotein and a negative correlation for HDL.

CONCLUSION:

Most studied biomarkers associated with SB were of cardiovascular or metabolic origin. There is a suggestion of a negative impact of SB on biomarkers but still a paucity of high quality investigations exist. Longitudinal studies with objectively measured SB are needed to further elucidate the pathophysiological pathways and possible associations of unexplored biomarkers.

• Authors: Katharina Wirth, Jochen Klenk, Simone Brefka, Dhayana Dallmeier, Kathrin Faehling, Marta Roqué I Figuls, Mark A Tully, Maria Giné-Garriga, Paolo Caserotti, Antoni Salvà, Dietrich Rothenbacher, Michael Denkinger, Brendon Stubbs, SITLESS consortium
• Journal: Ageing research reviews (Ageing Res Rev) Vol. 35 Pg. 87-111 (May 2017) ISSN: 1872-9649 [Electronic] England
• PMID: 28025174 (Publication Type: Journal Article, Review, Systematic Review)
• Copyright: Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

Chemical References

• Biomarkers
• Glycated Hemoglobin A
• Insulin
• Cholesterol

Topics

• Biomarkers (analysis, blood)
• Body Mass Index
• Cardiovascular Diseases (diagnosis, epidemiology, metabolism)
• Cholesterol (blood)
• Glycated Hemoglobin (analysis)
• Humans
• Insulin (blood)
• Middle Aged
• Risk Factors
• Sedentary Behavior
• Statistics as Topic