Inhibition of lung cancer in diethylnitrosamine-induced mice by Rhizoma paridis saponins.

Abstract

Lung cancer is the foremost cause of cancer mortality and a growing economic burden worldwide. Rhizoma paridis saponins (RPS) have been reported to exhibit potential anti-tumor effects on many kinds of tumor models. The present study was designed to investigate the mechanism-based chemopreventive nature of RPS against DEN-induced lung carcinogenesis in Kunming mice. As a result, the treatment with RPS reduced the severity of pulmonary histopathology. The mechanism of its antitumor effect involved in (a) reducing oxidative stress injury through up-regulating activities of CAT and SOD; (b) down-regulating the levels of inflammatory factors, like TNF-α, IL6, COX-2, and PGE2; (c) activation of caspase-3 and up-regulating the pro-apoptotic protein Bax; (d) decreasing the expression of PCNA; (e) depressing the expression of cancer stem cells marker CD133; (f) suppressing aberrant expression of cytokeratin 8 and 18; and (g) inhibiting EGFR/ PI3 K/Akt, EGFR/Ras/Erk and NF-κB pathways. Taken together, RPS would be a potent agent inhibiting lung tumor in the future.

• Authors: Shuli Man, Jing Li, Peiyu Qiu, Jing Liu, Zhen Liu, Long Ma, Wenyuan Gao
• Journal: Molecular carcinogenesis (Mol Carcinog) Vol. 56 Issue 5 Pg. 1405-1413 (05 2017) ISSN: 1098-2744 [Electronic] United States
• PMID: 27991692 (Publication Type: Journal Article)
• Copyright: © 2017 Wiley Periodicals, Inc.

Chemical References

• Antineoplastic Agents, Phytogenic
• Saponins
• Diethylnitrosamine
• EGFR protein, mouse
• ErbB Receptors

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Apoptosis (drug effects)
• Cell Proliferation (drug effects)
• Diethylnitrosamine (toxicity)
• ErbB Receptors (metabolism)
• Liliales (chemistry)
• Lung Neoplasms (chemically induced, drug therapy, pathology)
• Male
• Mice
• Neoplasms, Experimental (drug therapy)
• Neoplastic Stem Cells (drug effects, pathology)
• Oxidative Stress (drug effects)
• Rhizome (chemistry)
• Saponins (pharmacology)