Eph Receptor Tyrosine Kinases in Tumor Immunity.

Abstract

The family of Eph receptor tyrosine kinases and their ephrin ligands regulate a diverse array of physiologic processes, such as axonal guidance, bone remodeling, and immune cell development and trafficking. Eph/ephrin interactions have also been implicated in various pathologic processes, including inflammation, cancer, and tumor angiogenesis. Because Eph receptors play prominent roles in both the immune system and cancer, they likely impact the tumor immune microenvironment, an area in which Eph receptors remain understudied. Here, we provide the first comprehensive review of Eph receptors in the context of tumor immunity. With the recent rise of cancer immunotherapies as promising therapeutic interventions, further elucidation of the roles of Eph receptors in the tumor immune microenvironment will be critical for understanding and developing novel targets against tumor immune evasion. Cancer Res; 76(22); 6452-7. ©2016 AACR.

• Authors: Eileen Shiuan, Jin Chen
• Journal: Cancer research (Cancer Res) Vol. 76 Issue 22 Pg. 6452-6457 (11 15 2016) ISSN: 1538-7445 [Electronic] United States
• PMID: 27811149 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't)
• Copyright: ©2016 American Association for Cancer Research.

Chemical References

• Receptors, Eph Family

Topics

• Humans
• Neoplasms (immunology)
• Receptors, Eph Family (immunology)