[Antiamnesic effects divaza and its component model β-amyloid amnesia].

Abstract

AIM:

On amnesia models induced by (icv) injection of β-amyloid fragment 25-35 peptide were evaluated antiamnestic actitity.

MATERIAL AND METHODS:

It was used of active antibody preparations (RA AT) to protein S100 (tenoten), to eNOS (impaza) and combinations (divaza) antiamnestic activity behavioral tests novel object conditioned response passive avoidance.

RESULTS:

Under the influence of RA AT S100 observed recovery of violation of the β-amyloid short-term memory (1 hour after the initial presentation of objects), and RA AT eNOS were more effective when tested 24 hours later. Combined medication completely compensate for the simulated deflection behavior of rats did not differ from the intact control. The CRPA RA AT S100 had the greatest impact on the LP entry into the dark compartment, and RA AT eNOS influenced primarily on the emotional component of the reaction. When using the integrated product tends to increase the LP entry into the dark compartment was observed in the absence of changes in the number of boluses. Thus, tenoten had the greatest impact on cognitive impairment, impaza greater effect on the symptoms associated with surgery.

CONCLUSION:

Combined preparation divaza rendered more effective action, leveling and amnesia neophobia, which confirms the need for further research and prospect release of active drugs in models of neurodegenerative disorders.

• Authors: K K Ganinа, Yu L Duginа, E S Zhavbert, I A Ertuzun, O I Epstein, V N Mukhin, I N Abdurasulova
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) 2016 Vol. 116 Issue 9 Pg. 69-74 ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Antiamnesticheskoe deistvie divazy i ee komponentov na modeli β-amiloidnoi amnezii u krys.
• PMID: 27735902 (Publication Type: Journal Article)

Chemical References

• Amyloid beta-Peptides
• Antibodies
• IMPAZA
• Peptide Fragments
• S100 Proteins
• amyloid beta-protein (25-35)
• divaza
• tenoten

Topics

• Alzheimer Disease (drug therapy)
• Amnesia (chemically induced, drug therapy)
• Amyloid beta-Peptides (pharmacology)
• Animals
• Antibodies (pharmacology, therapeutic use)
• Avoidance Learning (drug effects)
• Disease Models, Animal
• Male
• Memory, Short-Term (drug effects)
• Peptide Fragments (pharmacology)
• Rats
• Rats, Wistar
• S100 Proteins (immunology)