Abstract | RATIONALE: OBJECTIVES: To further address this issue, we investigated the role of PPARγ on the development and expression of morphine withdrawal in mice and the effect of pioglitazone on several forms of heroin relapse in rats. METHODS: We induced physical dependence to morphine in mice by injecting morphine twice daily for 6 days. Withdrawal syndrome was precipitated on day 6 with an injection of naloxone. In addition, different groups of rats were trained to self-administer heroin and, after the extinction, the relapse was elicited by cues, priming, or stress. The effect of different doses of pioglitazone was tested on these different paradigms. RESULTS: CONCLUSIONS:
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Authors | Giordano de Guglielmo, Marsida Kallupi, Giulia Scuppa, Gregory Demopulos, George Gaitanaris, Roberto Ciccocioppo |
Journal | Psychopharmacology
(Psychopharmacology (Berl))
Vol. 234
Issue 2
Pg. 223-234
(Jan 2017)
ISSN: 1432-2072 [Electronic] Germany |
PMID | 27714428
(Publication Type: Journal Article)
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Chemical References |
- Analgesics, Opioid
- Narcotics
- Thiazolidinediones
- Heroin
- Morphine
- Pioglitazone
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Topics |
- Analgesics, Opioid
(administration & dosage)
- Animals
- Behavior, Addictive
(physiopathology, prevention & control, psychology)
- Conditioning, Operant
(drug effects, physiology)
- Heroin
(administration & dosage)
- Male
- Mice
- Morphine
(administration & dosage)
- Narcotics
(administration & dosage)
- Opioid-Related Disorders
(physiopathology, prevention & control, psychology)
- Pioglitazone
- Rats
- Rats, Wistar
- Recurrence
- Rodentia
- Self Administration
- Substance Withdrawal Syndrome
(physiopathology, prevention & control, psychology)
- Thiazolidinediones
(therapeutic use)
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