Abstract | BACKGROUND: The aim of this study was to test the hypothesis that prognosis in patients with cardiac amyloidosis is closely coupled with amyloid burden in all four cardiac chambers. The goal was to evaluate longitudinal strain (LS) in each cardiac chamber and to determine whether LS in specific cardiac chambers is preferentially associated with prognosis over conventional two-dimensional echocardiographic parameters in patients with cardiac amyloidosis. METHODS: RESULTS: LS in each chamber was significantly depressed in patients with both LV hypertrophy phenotypes compared with healthy subjects. Right atrial LS was significantly lower in patients with cardiac amyloidosis than those with nonobstructive hypertrophic cardiomyopathy after adjusting for LV ejection fraction and LV mass index. During a median follow-up period of 10 months, major adverse cardiovascular events developed in 22 patients with cardiac amyloidosis. Four-chamber LS were significantly associated with major adverse cardiovascular events, with incremental value over traditional echocardiographic parameters. CONCLUSIONS: Cardiac amyloidosis involves all cardiac chambers, and thus, chamber-specific strain analysis may be useful to assess the total cumulative burden of cardiac dysfunction.
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Authors | Yuichiro Kado, Masaru Obokata, Yasufumi Nagata, Tomoko Ishizu, Karima Addetia, Kazutaka Aonuma, Masahiko Kurabayashi, Roberto M Lang, Masaaki Takeuchi, Yutaka Otsuji |
Journal | Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
(J Am Soc Echocardiogr)
Vol. 29
Issue 11
Pg. 1092-1099.e2
(11 2016)
ISSN: 1097-6795 [Electronic] United States |
PMID | 27614542
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 American Society of Echocardiography. Published by Elsevier Inc. All rights reserved. |
Topics |
- Aged
- Amyloidosis
(diagnostic imaging, physiopathology)
- Echocardiography
(methods)
- Elastic Modulus
- Elasticity Imaging Techniques
(methods)
- Female
- Humans
- Hypertrophy, Left Ventricular
(diagnostic imaging, physiopathology)
- Male
- Middle Aged
- Reproducibility of Results
- Sensitivity and Specificity
- Severity of Illness Index
- Stress, Mechanical
- Stroke Volume
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