Abstract | BACKGROUND: Psychological stress is one of the major risk factors for asthma exacerbation. Although histamine in the brain acts as an excitatory and inhibitory neurotransmitter associated with psychological stress, the contribution of brain histamine to psychological stress-induced exacerbation of asthma remains unclear. The objective of this study was to investigate the role of histamine receptors in the CNS on stress induced asthma aggravation. METHODS: We monitored the numbers of inflammatory cells and interleukin (IL)-13 levels in bronchoalveolar lavage fluid, airway responsiveness to inhaled methacholine, mucus secretion in airway epithelial cells, and antigen-specific IgE contents in sera in a murine model of stress-induced asthma treated with epinastine (an H1R antagonist), thioperamide (an H3/4R antagonist), or solvent. RESULTS: All indicators of stress-induced asthma exacerbation were significantly reduced in stressed mice treated with epinastine compared with those treated with solvent, whereas treatment with thioperamide did not reduce the numbers of inflammatory cells in the stressed mice. CONCLUSIONS: These results suggest that H1R, but not H3/4R, may be involved in stress-induced asthma exacerbations in the central nervous system.
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Authors | Tomomitsu Miyasaka, Kaori Okuyama-Dobashi, Chiaki Masuda, Shunya Iwami, Miki Sato, Hirokazu Mizoguchi, Tasuku Kawano, Yuichi Ohkawara, Shinobu Sakurada, Motoaki Takayanagi, Isao Ohno |
Journal | Allergology international : official journal of the Japanese Society of Allergology
(Allergol Int)
Vol. 65 Suppl
Pg. S38-44
(Sep 2016)
ISSN: 1440-1592 [Electronic] England |
PMID | 27523601
(Publication Type: Journal Article)
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Copyright | Copyright © 2016 Japanese Society of Allergology. Production and hosting by Elsevier B.V. All rights reserved. |
Chemical References |
- Antigens
- Cytokines
- Histamine Antagonists
- Receptors, Histamine
- Immunoglobulin E
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Topics |
- Animals
- Antigens
(immunology)
- Bronchial Hyperreactivity
(etiology, metabolism, pathology)
- Bronchoalveolar Lavage Fluid
(immunology)
- Central Nervous System
(drug effects, metabolism)
- Cytokines
(biosynthesis)
- Disease Models, Animal
- Disease Progression
- Female
- Histamine Antagonists
(pharmacology)
- Immunoglobulin E
(blood, immunology)
- Mice
- Mucus
(metabolism)
- Receptors, Histamine
(metabolism)
- Stress, Psychological
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