Abstract | BACKGROUND: Hancornia speciosa Gomes (Apocynaceae), popularly known as "mangabeira," has been used in folk medicine to treat inflammatory disorders, hypertension, dermatitis, diabetes, liver diseases and gastric disorders. Although the ethnobotany indicates that its fruits can be used for the treatment of ulcers and inflammatory disorders, only few studies have been conducted to prove such biological activities. This study investigated the anti-inflammatory properties of the aqueous extract of the fruits of H. speciosa Gomes as well as its bioactive compounds using in vivo experimental models. METHODS: The bioactive compounds were identified by High Performance Liquid Chromatography coupled with diode array detector (HPLC-DAD) and Liquid Chromatography coupled with Mass Spectrometry (LC-MS). The anti-inflammatory properties were investigated through in vivo tests, which comprised xylene-induced ear edema, carrageenan-induced peritonitis and zymosan-induced air pouch. The levels of IL-1β, IL-6, IL-12 and TNF-α were determined using ELISA. RESULTS: CONCLUSION: This is the first study that demonstrated the anti-inflammatory activity of the extract of H. speciosa fruits against different inflammatory agents in animal models, suggesting that its bioactive molecules, especially rutin and chlorogenic acid are, at least in part, responsible for such activity. These findings support the widespread use of Hancornia speciosa in popular medicine and demonstrate that its aqueous extract has therapeutical potential for the development of herbal drugs with anti-inflammatory properties.
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Authors | Manoela Torres-Rêgo, Allanny Alves Furtado, Mariana Angélica Oliveira Bitencourt, Maira Conceição Jerônimo de Souza Lima, Rafael Caetano Lisbôa Castro de Andrade, Eduardo Pereira de Azevedo, Thaciane da Cunha Soares, José Carlos Tomaz, Norberto Peporine Lopes, Arnóbio Antônio da Silva-Júnior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa |
Journal | BMC complementary and alternative medicine
(BMC Complement Altern Med)
Vol. 16
Pg. 275
(Aug 05 2016)
ISSN: 1472-6882 [Electronic] England |
PMID | 27496015
(Publication Type: Journal Article)
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Chemical References |
- Anti-Inflammatory Agents
- Interleukins
- Plant Extracts
- Chlorogenic Acid
- Rutin
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Topics |
- Animals
- Anti-Inflammatory Agents
(chemistry, pharmacology)
- Apocynaceae
(chemistry)
- Chlorogenic Acid
(chemistry, pharmacology)
- Edema
- Female
- Fruit
(chemistry)
- Inflammation
(metabolism)
- Interleukins
(analysis)
- Male
- Mice
- Mice, Inbred BALB C
- Peritonitis
- Plant Extracts
(chemistry, pharmacology)
- Rutin
(chemistry, pharmacology)
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