Abstract | BACKGROUND AND AIMS: METHODS: Serum LRG concentrations were determined by enzyme-linked immunosorbent assay [ELISA] in consecutive 129 patients with UC in two tertiary care hospitals, and associations of LRG with clinical and endoscopic activities were evaluated. Clinical activity index [CAI] < 6 was defined as clinical remission, and mucosal healing [MH] and complete mucosal healing were defined as Matts' endoscopic grades of 1 or 2 and grade of 1, respectively. RESULTS: Serum LRG levels were significantly increased and correlated with clinical and endoscopic activities in patients with UC. LRG levels were associated with both clinical and endoscopic activities even in patients with normal serum C-reactive protein [CRP] levels. Furthermore, LRG levels were significantly lower in patients with complete MH and deep remission. Serial measurements of LRG levels in a subset of patients demonstrated that LRG was significantly elevated during the endoscopically active stage compared with that during the MH stage. CONCLUSIONS:
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Authors | Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hideki Iijima, Shinta Mizuno, Satoshi Serada, Minoru Fujimoto, Norimitsu Arai, Noriyuki Koyama, Eiichi Morii, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai, Tetsuo Takehara, Tetsuji Naka |
Journal | Journal of Crohn's & colitis
(J Crohns Colitis)
Vol. 11
Issue 1
Pg. 84-91
(Jan 2017)
ISSN: 1876-4479 [Electronic] England |
PMID | 27466171
(Publication Type: Journal Article)
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Copyright | © European Crohn’s and Colitis Organisation (ECCO) 2016. |
Chemical References |
- Biomarkers
- Glycoproteins
- LRG1 protein, human
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Topics |
- Adult
- Aged
- Biomarkers
(blood)
- Case-Control Studies
- Colitis, Ulcerative
(diagnosis, pathology)
- Endoscopy, Gastrointestinal
- Enzyme-Linked Immunosorbent Assay
- Female
- Glycoproteins
(blood)
- Humans
- Intestinal Mucosa
(pathology)
- Male
- Middle Aged
- Young Adult
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