Abstract |
Coxibs are a class of powerful drugs used by millions of people worldwide to treat a wide variety of ailments such as muscular skeletal pain and inflammation. The primary mechanism of action of coxibs is the potent inhibition of the COX-2 enzyme. Unfortunately, their use is limited to patients due to a variety of factors including poor solubility, negative effects on renal clearance and increased risk of cardiovascular pathology. However, because of their effectiveness in blocking PGE2 mediated inflammation, a key pathway that drives many diseases, there is a clear unmet medical need to develop new COX-2 inhibitors that are free of the aforementioned problems. The purpose of this prospectus is to define the specific properties that are desired in 3rd generation coxibs as a starting point for the development of new and better drugs.
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Authors | Micky D Tortorella, Yanmei Zhang, John Talley |
Journal | Mini reviews in medicinal chemistry
(Mini Rev Med Chem)
Vol. 16
Issue 16
Pg. 1284-1289
( 2016)
ISSN: 1875-5607 [Electronic] Netherlands |
PMID | 27156517
(Publication Type: Journal Article, Review)
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Chemical References |
- Cyclooxygenase 2 Inhibitors
- Cyclooxygenase 2
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Topics |
- Cyclooxygenase 2
(metabolism)
- Cyclooxygenase 2 Inhibitors
(chemistry, pharmacology)
- Humans
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