Abstract | OBJECTIVES:
Intracerebral hemorrhage (ICH) is a type of stroke that results in significant mortality and morbidity. Currently there is no definitive treatment for this disease. The paucity of animal models that reflect the heterogeneity of this spontaneous human disease could be the reason. METHODS: In this review, we searched the literature for animal models of spontaneous ICH and found eight relevant papers. RESULTS: CONCLUSIONS: While all of the spontaneous ICH models have some advantages, the disadvantages include the sporadic time of onset of ICH and variability in size and location of ICH. Since there are no known efficacious treatments for ICH, it is not known if findings in the animal models will find treatments that are effective in humans.
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Authors | Bader Murshed Alharbi, Michael K Tso, R Loch Macdonald |
Journal | Neurological research
(Neurol Res)
Vol. 38
Issue 5
Pg. 448-55
(May 2016)
ISSN: 1743-1328 [Electronic] England |
PMID | 27098341
(Publication Type: Journal Article, Review)
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Topics |
- Animals
- Cerebral Amyloid Angiopathy
(complications, genetics)
- Cerebral Hemorrhage
(etiology)
- Disease Models, Animal
- Humans
- Hypertension
(complications, genetics)
- Mice, Transgenic
- Risk Factors
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