Therapeutic Effect of Carboxyamidotriazole on Adjuvant Arthritis in Rats.

Abstract

OBJECTIVE:

To study the effect of carboxyamidotriazole (CAI) on adjuvant arthritis (AA) in rats.

METHODS:

The rats were randomly divided into normal group,two vehicle groups (polyethylene glycol 400 control and normal sodium control group), CAI-treated groups (10, 20, and 40 mg/kg) and positive control dexamethasone group. Freund's completed adjuvant was used to induce AA in rats. The arthritis index (AI) was scored, and X-ray check of the hind limbs and histopathological examination were performed. The levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in the inflamed paw tissues were measured.

RESULTS:

The administration of CAI significantly decreased the AI, restored the body weights, and ameliorated the radiological and histopathological features of joint destruction in AA rats (P<0.05, P<0.01). In addition, CAI reduced the TNF-α, IL-1β, and IL-6 levels in the inflamed paw tissues (P<0.05, P<0.01).

CONCLUSION:

CAI has therapeutic effect on AA rats, which may be achieved by decreasing the pro-inflammatory cytokines at the site of inflammation.

• Authors: Lei Zhu, Juan Li, Lei Guo, Xiao-li Yu, Dan-wei Wu, Wei Chen, Chen Chen, Xiao-wan Du, De-chang Zhang, Cai-ying Ye
• Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 38 Issue 1 Pg. 49-54 (Feb 2016) ISSN: 1000-503X [Print] China
• PMID: 26956856 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-1beta
• Interleukin-6
• Triazoles
• Tumor Necrosis Factor-alpha
• carboxyamido-triazole
• Freund's Adjuvant

Topics

• Animals
• Arthritis, Experimental
• Freund's Adjuvant
• Interleukin-1beta
• Interleukin-6
• Rats
• Triazoles
• Tumor Necrosis Factor-alpha