Serum lipoprotein(a) levels and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus.

Abstract

AIMS:

We aimed to evaluate the association between serum lipoprotein(a) [Lp(a)] levels and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus.

METHODS:

This study included 581 patients with type 2 diabetes mellitus. Serum Lp(a) levels were divided into four groups; the cut-off points were at the 30th, 60th, and 90th percentile values on the basis of the distribution for all subjects. Diabetic nephropathy was defined as present when the urinary albumin-creatinine ratio was ≥33.9mg/mmol creatinine and/or the estimated glomerular filtration rate was <30ml/min/1.72m(2). Adjustment was made for age, sex, body mass index, hemoglobin A1c, duration of diabetes mellitus, current drinking, current smoking, hypertension, dyslipidemia, coronary heart disease, and stroke.

RESULTS:

Higher serum Lp(a) levels were significantly associated with a higher prevalence of diabetic nephropathy: the adjusted odds ratios (95% confidence intervals) for diabetic nephropathy in relation to serum Lp(a) levels of ≤6, 7-15, 16-38, and ≥39mg/dl were 1.00 (reference), 2.74 (1.08-7.00), 3.31 (1.28-8.54), and 4.80 (1.57-14.60), respectively (P for trend=0.004).

CONCLUSIONS:

The results suggest that serum Lp(a) levels may be positively associated with diabetic nephropathy among Japanese patients with type 2 diabetes mellitus.

• Authors: Hidenori Senba, Shinya Furukawa, Takenori Sakai, Tetsuji Niiya, Teruki Miyake, Shin Yamamoto, Teruhisa Ueda, Masamoto Torisu, Hisaka Minami, Hiroaki Miyaoka, Morikazu Onji, Keiko Tanaka, Bunzo Matsuura, Takeshi Tanigawa, Yoichi Hiasa, Yoshihiro Miyake
• Journal: Journal of diabetes and its complications (J Diabetes Complications) Vol. 30 Issue 5 Pg. 923-7 (07 2016) ISSN: 1873-460X [Electronic] United States
• PMID: 26947887 (Publication Type: Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Lipoprotein(a)

Topics

• Adult
• Aged
• Aged, 80 and over
• Albuminuria (etiology)
• Cohort Studies
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (complications)
• Diabetic Nephropathies (blood, epidemiology, physiopathology, urine)
• Female
• Humans
• Japan (epidemiology)
• Lipoprotein(a) (blood)
• Male
• Middle Aged
• Prevalence
• Prospective Studies
• Renal Insufficiency (blood, complications, epidemiology, physiopathology)
• Severity of Illness Index
• Up-Regulation
• Young Adult