Effect of a long term very low calorie diet on glucose/insulin metabolism in obesity. Influence of fat distribution on hepatic insulin extraction.

Abstract	Hyperinsulinemia is a well-recognized entity of simple obesity. In upper body obesity a diminished hepatic extraction of insulin contributes to the hyperinsulinemia. SHBG levels correlate (r = 0.34, P less than 0.05) with the c-peptide/insulin molar ratio. After long term weight reduction by very low calorie dieting, not only fasting and total area insulin decreased significantly, also hepatic insulin extraction improved markedly. This observed change was related to an increase in SHBG both for men and women.
Authors	L Van Gaal, G Vansant, K Van Acker, I De Leeuw
Journal	International journal of obesity (Int J Obes) Vol. 13 Suppl 2 Pg. 47-9 ( 1989) England
PMID	2693384 (Publication Type: Journal Article)
Chemical References	Insulin Glucose
Topics	Adult Body Composition Diet, Reducing Energy Intake Female Glucose (metabolism) Humans Hyperinsulinism (etiology) Insulin (metabolism) Liver (metabolism) Obesity (complications, diet therapy, metabolism) Weight Loss

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