Abstract | CONTEXT: OBJECTIVE: Our objective was to investigate the effects of pramlintide, known to suppress glucagon and delay gastric emptying, on postprandial glucose fluxes in T1D. DESIGN: This was a single-center, inpatient, randomized, crossover study. PATIENTS: Twelve patients with T1D who completed the study were analyzed. INTERVENTIONS: MAIN OUTCOME MEASURE:
Glucose turnover and SI were the main outcome measures. RESULTS: With pramlintide, 2-hour postprandial glucose, insulin, glucagon, glucose turnover, and SI indices showed: plasma glucose excursions were reduced (difference in incremental area under the curve [iAUC], 444.0 mMmin, P = .0003); plasma insulin concentrations were lower (difference in iAUC, 7642.0 pMmin; P = .0099); plasma glucagon excursions were lower (difference in iAUC, 1730.6 pg/mlmin; P = .0147); meal rate of glucose appearance was lower (difference in iAUC: 1196.2 μM/kg fat free mass [FFM]; P = .0316), endogenous glucose production was not different (difference in iAUC: -105.5 μM/kg FFM; P = .5842), rate of glucose disappearance was lower (difference in iAUC: 1494.2 μM/kg FFM; P = .0083). SI and liver insulin sensitivity were not different between study visits (P > .05). CONCLUSIONS: Inhibition of glucagon and gastric emptying delaying reduced 2-hour prandial glucose excursions in T1D by delaying meal rate of glucose appearance.
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Authors | Ling Hinshaw, Michele Schiavon, Vikash Dadlani, Ashwini Mallad, Chiara Dalla Man, Adil Bharucha, Rita Basu, Jennifer R Geske, Rickey E Carter, Claudio Cobelli, Ananda Basu, Yogish C Kudva |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 101
Issue 5
Pg. 1954-62
(05 2016)
ISSN: 1945-7197 [Electronic] United States |
PMID | 26930181
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
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Chemical References |
- Blood Glucose
- Hypoglycemic Agents
- Islet Amyloid Polypeptide
- pramlintide
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Topics |
- Adult
- Aged
- Blood Glucose
(metabolism)
- Cross-Over Studies
- Diabetes Mellitus, Type 1
(blood, drug therapy)
- Female
- Humans
- Hypoglycemic Agents
(therapeutic use)
- Insulin Resistance
(physiology)
- Islet Amyloid Polypeptide
(therapeutic use)
- Male
- Middle Aged
- Postprandial Period
(drug effects)
- Treatment Outcome
- Young Adult
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