Abstract |
This review aims at presenting a new concept pertaining to the development of antioxidants, namely, to evolve from disease-oriented therapy to mechanism-oriented therapy. Using as our illustrative example is DJ-1, a homodimeric protein that is ubiquitously expressed in a variety of mammalian tissues, including the brain, and is found in the matrix and the intermembrane space of the mitochondria. DJ-1 is known to be an endogenous antioxidant against cancer, neurodegeneration and cardiovascular diseases, of which oxidative stress plays a causal role. Interestingly, the mechanistic targets of DJ-1 as an antioxidant, including Daxx, Nrf2, thioredoxin, glutathione, α- synuclein, PTEN/PI3K/Akt, and Pink/Parkin are also associated with those oxidative stress-related diseases. Furthermore, activators of DJ-1 are available in the form of mortalin, phenylbutyrate and NAD(P)H:
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Authors | Julie Y H Chan, Samuel H H Chan |
Journal | Pharmacology & therapeutics
(Pharmacol Ther)
Vol. 156
Pg. 69-74
(Dec 2015)
ISSN: 1879-016X [Electronic] England |
PMID | 26432617
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Antioxidants
- Intracellular Signaling Peptides and Proteins
- Oncogene Proteins
- Reactive Oxygen Species
- PARK7 protein, human
- Protein Deglycase DJ-1
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Topics |
- Antioxidants
(metabolism)
- Cardiovascular Diseases
(metabolism)
- Humans
- Intracellular Signaling Peptides and Proteins
(agonists, biosynthesis)
- Neoplasms
(metabolism)
- Neurodegenerative Diseases
(metabolism)
- Oncogene Proteins
(agonists, biosynthesis)
- Parkinson Disease
(metabolism)
- Protein Deglycase DJ-1
- Reactive Oxygen Species
(metabolism)
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