mortalin

01/01/2017 - "In this study, we report that upregulation of mortalin contributes to cancer cell stemness. "
11/01/2013 - "To the best of our knowledge, the study provides a first demonstration of transcellular crosstalk between stromal cells and BCCs that involve direct contact and may also include a transfer of mortalin, an anti-apoptotic and growth-promoting factor enriched in cancer cells. "
11/25/1997 - "We have performed immunohistochemical studies of mortalin in normal and tumor human brain sections. "
11/01/2023 - "Clinical evidence suggests a drastic depletion of the overall survival time of cancer patients with high mortalin expression. "
01/01/2023 - "Conclusions: Our findings demonstrate a previously unknown mortalin profile in peripheral and local tumor ecosystem and its clinical relevance in OC. "

01/01/2019 - "Previous studies show that mortalin, a HSP70 family member, contributes to the development and progression of ovarian cancer. "
11/01/2016 - "The aim of this study is to elucidate the mechanism of mortalin in ovarian cancer development and progression. "
11/01/2016 - "Previous studies have suggested that mortalin contributes to ovarian cancer development and progression, but further investigation is warranted. "
08/09/2013 - "In this study, an assessment of mortalin expression using ovarian cancer tissue microarrays suggested that mortalin overexpression might be related to drug resistance. "
01/01/2023 - "Clinical Relevance of Mortalin in Ovarian Cancer Patients."

10/01/2018 - "Finally, a bioinformatic analysis demonstrated that a high level of mortalin expression correlates with a worse survival prognosis for glioma patients. "
04/10/1997 - "However, a deregulation of the expression is observed in rat brain tumor along with the detection of nonpancytosolic mortalin in rat glioma cell line C6. "
09/15/2015 - "Screening through MTT assay as well as the phase contrast micrographs and Confocal images of immunostained C6 Glioma cells for markers such as α-tubulin, GFAP, mortalin and HSP-70 cells indicated that the compounds possess significant antiproliferative activity. "
01/01/2016 - "Reduction in glial fibrillary acidic protein (GFAP) and upregulation of mortalin and neural cell adhesion molecule (NCAM) expression specifically in tumor-bearing tissue further indicated the anti-glioma efficacy of ASH-WEX in vivo. "

10/11/2017 - "These results support the utility of knockdown of mortalin to induce apoptosis and reduce ECMs expression in keloid spheroid, which may be highly beneficial in treating keloids."
10/11/2017 - "Knockdown of mortalin relocated p53 to the cell nucleus in primary keloid spheroids by dE1-RGD/GFP/shMot transduction. "
10/11/2017 - "Therefore, we generated mortalin-specific small hairpin (sh) RNAs (dE1-RGD/GFP/shMot) and introduced into keloid spheroids for examination of its apoptotic and anti-fibrotic effect. "
07/18/2022 - "Thus, dE1-RGD/GEP/shMot can inhibit the TGF-β/α-SMA axis and NF-κB signal pathways in scar formation, and blocking endogenous mortalin could be a potential therapeutic target for keloids."
10/11/2017 - "Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids."

01/01/2016 - "In the present study, we examined the clinical relevance of mortalin upregulation in carcinogenesis. "
07/01/2010 - "In the present study, we selected mortalin, a stress chaperone that is tightly involved in human carcinogenesis, constructed a mortalin-targeting Adon (mot-Adon) virus and examined its therapeutic potential both in vitro and in vivo. "
10/15/2005 - "Taken together, this study for the first time delineates: (i) molecular interactions of HSP60 with mortalin; (ii) their co- and exclusive localizations in vivo; (iii) their involvement in tumorigenesis; and (iv) their functional distinction in pathways involved in senescence."
11/01/2016 - "Oncogenic role of mortalin contributes to ovarian tumorigenesis by activating the MAPK-ERK pathway."
09/05/2014 - "Identification and functional characterization of nuclear mortalin in human carcinogenesis."