benzoquinone (quinone)

11/25/2015 - "This study has demonstrated the first example of a rapid, selective, and sensitive phosphorescence probe based on phosphorescence energy transfer (PET) for cancer-associated human quinone oxidoreductase isozyme 1 (NQO1). "
12/15/2014 - "Previous studies suggested that redox activation of beta-Lp catalyzed by quinone oxidoreductase 1 (NQO1) accounted for its killing of cancer cells. "
08/01/2014 - "The present study demonstrates that five of the quinone-containing compounds induced apoptosis in human cancer cells and are therefore promising lead compounds for the development of novel anticancer drugs."
11/01/2013 - "To explore active anticolorectal cancer compounds, we carried out phytochemical studies on Alkanna tinctoria and isolated eight quinone compounds. "
11/01/2015 - "This implies that tumors can be preferentially damaged relative to normal tissue by cytotoxic quinone drugs. "

12/01/1950 - "Experimental studies on the skin- and lung-cancer, produced by the nonreduced quinone."
03/01/2015 - "The role of genetic polymorphisms of quinone oxidoreductase 1 (NQO1), which is known to be related to carcinogen metabolism and oxidative status, was evaluated for lung cancer development. "
02/28/2015 - "Cytotoxicity assays using A549 and H596 lung cancer cells showed that both micelle formulations maintained quinone oxidoreductase 1 (NQO1)-dependent cytotoxicity. "
11/17/2014 - "Evaluation of the mutagenicity of anti-B[a]P-diol epoxide with B[a]P-7,8-dione on p53 showed that the o-quinone produced by AKRs was the more potent mutagen, provided that it was permitted to redox cycle, and that the mutations observed were G to T transversions, reminiscent of those observed in human lung cancer. "
12/01/2013 - "No clear consensus has been reached on the quinone oxidoreductase 1 (NQO1) gene C609T polymorphism and lung cancer risk. "

08/23/2013 - "Interestingly, the remaining quinone in 2 was required for its cytotoxicity, as the 5,8,15,18-O-tetraacetylated bishydroquinone derivative (3) exhibited weak cytotoxicity compared to 1 and 2. The present study demonstrates a simple way to eliminate the undesired accidental necrosis inducing effect of substances that may be developed as improved anticancer drug candidates. "
08/23/2013 - "The presence of two quinone moieties in its structure was demonstrated to induce accidental necrosis and increase reactive oxygen species (ROS) levels. "
05/01/2006 - "We have labelled hypericin, a polyphenolic polycyclic quinone found in St. John's wort (Hypericum perforatum), with( 123)I and evaluated mono-[(123)I]iodohypericin (MIH) as a potential necrosis-avid diagnostic tracer agent. "
02/01/2006 - "An overdose of acetaminophen (APAP) (N-acetyl-p-aminophenol) leads to hepatocellular necrosis induced by its metabolite N-acetyl-p-benzoquinone-imine, which is generated during the metabolic phase of liver intoxication. "
02/01/1998 - "We also monitored the nuclear envelope in living cells after induction of apoptosis or necrosis using 1 microM staurosporine or 100 microM p-benzoquinone, respectively. "

08/01/2000 - "Previous investigations have proposed a mode of action involving metabolism to a quinone-imine, the formation of protein adducts, cell death, and compensatory hyperplasia leading to the observed adenomas. "
03/01/2009 - "NRH:quinone oxidoreductase 2 (NQO2) is known to protect against myelogenous hyperplasia. "
06/01/2002 - "Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia."
04/01/2006 - "Human NRH:quinone oxidoreductase 2 (NQO2) is a cytosolic protein that catalyzes the metabolic reduction of quinones and provides protection against myelogenous hyperplasia and chemical carcinogenesis. "
05/30/2005 - "Quinone oxidoreductases in protection against myelogenous hyperplasia and benzene toxicity."

12/01/2008 - "Our investigation suggests that quinone species, intracellular GSH depletion, ROS formation, and mitochondrial toxicity significantly contributed toward ASA selective toxicity in melanocytic SK-MEL-28 melanoma cells."
11/18/2006 - "We therefore concluded that quinone formation was the major pathway for 4-HA induced toxicity in B16-F0 melanoma cells whereas free radical formation played a negligible role in the 4-HA induced toxicity."
02/24/2000 - "One quinone displayed the novel feature of cytotoxicity selectively against melanoma cell lines. "
01/01/1988 - "The selective toxic action of anisyl quinone in the treatment of melanoma may, in part, be due to membrane defects in the melanosomes of malignant melanocytes."
02/12/2010 - "The aim of this study was to identify a phenolic prodrug compound that is minimally metabolized by rat liver microsomes, but yet could form quinone reactive intermediates in melanoma cells as a result of its bioactivation by tyrosinase. "