Abstract | BACKGROUND: METHODS: We performed a cross-sectional study of a cohort of 80 patients with end-stage renal disease receiving PD. Peritoneal transport characteristics were identified and after peritoneal equilibration test patients were grouped as high (high(H)/high-average (HA) group, n = 31) or low (low (L)/low-average (LA) group, n = 49) transporters. The redox state of human serum albumin was measured using high-performance liquid chromatography. RESULTS: The fraction of human mercaptoalbumin (HMA) showed significantly higher values in patients with high transport status than those with low transport status (f(HMA) 64.0 ± 5.4 and 52.7 ± 10.4%, respectively). Our data showed that the H/HA transport characteristic was associated with lower albumin (3.76 ± 0.48 vs. 4.00 ± 0.35, p < 0.05), and lower levels of advanced oxidized protein product (p = 0.008) when compared with the L/LA type. A correlation analysis showed that there was a positive correlation between dialysate/plasma (D/P) creatinine and f(HMA) levels (r = 0.511, p < 0.0001), as well as hemoglobin levels r = 0.231, p = 0.044 and a negative correlation between D/P creatinine and serum albumin, cholesterol and LDL levels (r = -0.236, p = 0.039; r = -0.237, p = 0.038; r = -0.272, p = 0.018, respectively). CONCLUSIONS: This study showed that higher serum levels of reduced albumin f(HMA) appear to be associated with high/high average peritoneal membrane transport characteristics in the incident PD patients.
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Authors | Paik Seong Lim, Hung-Ping Chen, Chang-Hsu Chen, Ming Yin Wu, Chuen Yuh Wu, Tsai-Kun Wu |
Journal | Blood purification
(Blood Purif)
Vol. 40
Issue 3
Pg. 243-9
( 2015)
ISSN: 1421-9735 [Electronic] Switzerland |
PMID | 26406805
(Publication Type: Journal Article)
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Copyright | © 2015 S. Karger AG, Basel. |
Chemical References |
- Antioxidants
- Glycation End Products, Advanced
- Hemoglobins
- Lipoproteins, LDL
- Membranes, Artificial
- Serum Albumin
- mercaptoalbumin
- Cholesterol
- Creatinine
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Topics |
- Adult
- Aged
- Antioxidants
(chemistry, metabolism)
- Biological Transport
- Cholesterol
(blood)
- Cohort Studies
- Creatinine
(blood)
- Cross-Sectional Studies
- Female
- Glycation End Products, Advanced
(blood)
- Hemoglobins
(metabolism)
- Hemorheology
- Humans
- Kidney Failure, Chronic
(blood, pathology, therapy)
- Kidneys, Artificial
- Lipoproteins, LDL
(blood)
- Male
- Membranes, Artificial
- Middle Aged
- Oxidation-Reduction
- Peritoneal Dialysis, Continuous Ambulatory
(instrumentation)
- Regression Analysis
- Serum Albumin
(chemistry, metabolism)
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