Experimental Study of the Mechanisms of Intracellular Defense in Cardiomyocytes Associated with Stages of Anthracosilicosis Development.

Mechanisms of intracellular defense of rat cardiomyocytes were studied in dynamics of anthracosilicosis development induced by long-term inhalation of coal and rock dust. It was shown that synthesis of transcription factor HIF-1α and protective proteins increased in the heart at the early stages of coal and rock dust inhalation (1-3 weeks), and these changes limited the development of free radical oxidation and activated metabolism of glucose and fatty acids. Exposure to coal and rock dust for 6-12 weeks activated free radical oxidation and decreased basal metabolism in cardiomyocytes.
AuthorsV V Zakharenkov, N N Mikhailova, N N Zhdanova, L G Gorokhova, A G Zhukova
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 159 Issue 4 Pg. 431-4 (Aug 2015) ISSN: 1573-8221 [Electronic] United States
PMID26388578 (Publication Type: Journal Article)

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