The value of cytoplasmic Y-box-binding protein 1 as a prognostic marker for breast cancer in Korean.

Abstract

BACKGROUND:

The human Y-box-binding protein 1 (YB-1) is a member of the DNA/RNA-binding family of proteins that regulates transcription and translation of genes. Previous studies suggest that YB-1 may have an oncogenic role in various cancers. In this study, we evaluate the prognostic value of cytoplasmic YB-1 with respect to breast cancer.

METHODS:

Immunohistochemical staining study was performed with YB-1 using tissue block from 233 patients with invasive ductal carcinoma. Patients were divided into two groups according to expression of cytoplasmic YB-1 in tumor cell (high versus low). The relationship between the expression of YB-1, clinicopathological characteristics and breast cancer prognosis was analyzed.

RESULTS:

Hormone receptor negativity, worse histologic and nuclear grade, high tumor stage, lymphovascular invasion and high Ki67 (≥14 %) were related with the increased expression of cytoplasmic YB-1 in tumor cell (p < 0.05). Although there was no significant difference in relapse-free survival (RFS) between the two groups (p = 0.412), difference in overall survival (OS) was statistically significant (p = 0.035). In multivariate analysis for OS, YB-1 was an independent prognostic factor (p = 0.043).

CONCLUSION:

This suggests that the increased expression of cytoplasmic YB-1 in tumor cells can be regarded as an independent prognostic factor for breast cancer, related to poor prognostics. Expression of cytoplasmic YB-1 in cancer cell could be used as an independent prognostic marker for predicting OS in breast cancer.

• Authors: Anbok Lee, Juhyun Woo, Heejung Park, Sun Hee Sung, Ju-Young Seoh, Woosung Lim, Byung-In Moon
• Journal: Breast cancer (Tokyo, Japan) (Breast Cancer) Vol. 23 Issue 5 Pg. 685-91 (Sep 2016) ISSN: 1880-4233 [Electronic] Japan
• PMID: 26193840 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Y-Box-Binding Protein 1
• YBX1 protein, human

Topics

• Adult
• Asian People
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (metabolism, mortality, pathology)
• Cytoplasm (metabolism)
• Female
• Humans
• Kaplan-Meier Estimate
• Middle Aged
• Prognosis
• Y-Box-Binding Protein 1 (metabolism)