Abstract |
Hydrogels have gained significant attention as ideal delivery vehicles for protein drugs. However, the use of hydrogels for protein delivery has been restricted because their porous structures inevitably cause a premature leakage of encapsulated proteins. Here, we report a simple yet effective approach to regulate the protein release kinetics of hydrogels through the creation of microstructures, which serve as a reservoir, releasing their payloads in a controlled manner. Microstructured dextran hydrogels enable burst-free sustained release of PEGylated interferon over 3 months without compromising its bioactivity. These hydrogels substantially extend the circulation half-life of PEGylated interferon, allowing for less frequent dosing in a humanized mouse model of hepatitis C. The present approach opens up possibilities for the development of sustained protein delivery systems for a broad range of pharmaceutical and biomedical applications.
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Authors | Ki Hyun Bae, Fan Lee, Keming Xu, Choong Tat Keng, Sue Yee Tan, Yee Joo Tan, Qingfeng Chen, Motoichi Kurisawa |
Journal | Biomaterials
(Biomaterials)
Vol. 63
Pg. 146-57
(Sep 2015)
ISSN: 1878-5905 [Electronic] Netherlands |
PMID | 26100344
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2015 Elsevier Ltd. All rights reserved. |
Chemical References |
- Antiviral Agents
- Delayed-Action Preparations
- Dextrans
- Hydrogels
- Interferon-alpha
- Polyethylene Glycols
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Topics |
- Animals
- Antiviral Agents
(administration & dosage, chemistry, pharmacokinetics, therapeutic use)
- Cell Line, Tumor
- Delayed-Action Preparations
(chemistry)
- Dextrans
(chemistry)
- Hepacivirus
(drug effects, isolation & purification)
- Hepatitis C
(drug therapy, pathology)
- Humans
- Hydrogels
(chemistry)
- Interferon-alpha
(administration & dosage, chemistry, pharmacokinetics, therapeutic use)
- Liver
(pathology, virology)
- Male
- Mice
- Polyethylene Glycols
(chemistry)
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