The purpose of this study is to identify significant immune-system related for symptom of patients with prostatic
inflammation in order to investigate the etiology of prostatic
inflammation which may relate to potentially chronic
prostatitis (CP). We investigated the expression of immune system-related
biomarkers such as
Interleukin (IL) -6 (humoral immunity), CD-3 (T-lymphocyte), and CD-163 (macrophage) in prostate biopsy (PBx) specimens from patients with prostatic
inflammation (without
cancer) which had been neither clinically diagnosed
benign prostatic hyperplasia nor chronic
prostatitis. We examined the correlation between these markers' expressions and the symptom scores using the National Institutes of Health-Chronic
Prostatitis Symptom Index (NIH-CPSI), International Prostate Symptom Score (IPSS)/quality of life (QOL) which are the index for
lower urinary tract symptoms (LUTS). Our results showed CD-163 (macrophage) reflected
pain or discomfort on NIH-CPSI scores (P=0.0389 and r=0.3307) in the patients with prostatic
inflammation; however, the control patients had no significant correlation between symptom scores and those immune-related markers' expression. These results suggest that
pain or discomfort related to macrophages in the relationship between immune-system and the symptom of prostatic
inflammation. In conclusion, CD-163, related to immune-system (macrophage), correlated with symptoms (
pain or discomfort) of prostatic
inflammation and might represent a significant immune-system related
biomarker for
pain or LUTS score in potentially CP.